Gas Chromatographic-mass Spectrometric Analysis of Volatiles Obtained by Four Different Techniques From Salvia Rosifolia Sm., and Evaluation for Biological Activity

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dc.contributor.authorÖzek, Gülmira
dc.contributor.authorDemirci, Fatih
dc.contributor.authorÖzek, Temel
dc.contributor.authorTabanca, Nurhayat
dc.contributor.authorWedge, David E.
dc.contributor.authorKhan, Shabana I.
dc.contributor.authorBaşer, Kemal Hüsnü Can
dc.contributor.authorDuran, Ahmet
dc.contributor.authorHamzaoğlu, Ergin
dc.date.accessioned2020-03-26T17:48:53Z
dc.date.available2020-03-26T17:48:53Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractFour different isolation techniques, conventional hydrodistillation (HD), microwave-assisted hydrodistillation (MWHD), microdistillation (MD) and micro-steam distillation-solid-phase microextraction (MSD-SPME), have been used to analyze the volatile constituents from the aerial parts of Salvia rosifolia Sm. by gas chromatography and gas chromatography coupled to mass spectrometry. HD and MWHD techniques produced quantitatively (yield, 0.39% and 0.40%) and qualitatively (aromatic profile) similar essential oils. alpha-Pinene (15.7-34.8%), 1,8-cineole (16.6-25.1%), beta-pinene (6.7-13.5%), beta-caryophyllene (1.4-5.0%) and caryophyllene oxide (1.4-4.4%) were identified as major constituents of this Turkish endemic species. Besides, the hydrodistilled oil of S. rosifolia was evaluated for antibacterial, antifungal, anticancer, antioxidant and cytotoxic activities. The hydrodistilled oil of S. rosifolia showed antibacterial activity against Methicillin-resistant Staphylococcus aureus (MRSA) with a MIC value of 125 mu g/mL Other human pathogenic microorganisms (Escherichia coli, Pseudomonas aeruginosa, Enterobacter aerogenes, Salmonella typhimurium, Staphylococcus epidermidis, Candida albicans) were also inhibited within a moderate range (MIC = 125-1000 mu g/mL). Antifungal activity of the oil was also observed against the strawberry anthracnose-causing fungal plant pathogens Colletotrichum acutatum, C. fragariae and C. gloeosporioides. No cytotoxicity was observed for S. rosifolia oil up to 25 mg/mL against malignant melanoma, epidermal, ductal and ovary carcinoma.en_US
dc.identifier.citationÖzek, G., Demirci, F., Özek, T., Tabanca, N., Wedge, D. E., Khan, S. I., Başer, K. H. C., Duran, A., Hamzaoğlu, E., (2010). Gas Chromatographic-mass Spectrometric Analysis of Volatiles Obtained by Four Different Techniques From Salvia Rosifolia Sm., and Evaluation for Biological Activity. Journal of Chromatography A, (1217), 741-748. Doi: 10.1016/j.chroma.2009.11.086
dc.identifier.doi10.1016/j.chroma.2009.11.086en_US
dc.identifier.endpage748en_US
dc.identifier.issn0021-9673en_US
dc.identifier.issn1873-3778en_US
dc.identifier.pmid20015509en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage741en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.chroma.2009.11.086
dc.identifier.urihttps://hdl.handle.net/20.500.12395/24957
dc.identifier.volume1217en_US
dc.identifier.wosWOS:000274351600017en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDuran, Ahmet
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Chromatography Aen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectSalvia rosifoliaen_US
dc.subjectEssential oilen_US
dc.subjectHydrodistillationen_US
dc.subjectMicrowaveen_US
dc.subjectMicrodistillationen_US
dc.subjectSolid-phase microextractionen_US
dc.subjectalpha-Pineneen_US
dc.subject1,8-Cineoleen_US
dc.subjectBiological activityen_US
dc.titleGas Chromatographic-mass Spectrometric Analysis of Volatiles Obtained by Four Different Techniques From Salvia Rosifolia Sm., and Evaluation for Biological Activityen_US
dc.typeArticleen_US

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