Doxycycline and meloxicam can treat neuroinflammation by increasing activity of antioxidant enzymes in rat brain

Basit Öğe Kaydı
dc.contributor.authorDik, Burak.
dc.contributor.authorCoskun, Devran.
dc.contributor.authorBahcivan, Emre.
dc.contributor.authorEr, Ayse.
dc.date.accessioned2020-03-26T20:13:31Z
dc.date.available2020-03-26T20:13:31Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Veteriner Fakültesi, Klinik Öncesi Bilimler Bölümüen_US
dc.description.abstractThe aim of this study is to determine the effects of alone or combined usage of doxycycline and meloxicam on brain superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), and matrix metalloproteinase (MMP)-9 levels of lipopolysaccharide (LPS)-induced brain inflammation. Totally 78 rats were divided into 5 groups; Healthy control (n=6), LPS (n=18, 0.05 mu g/mu L/rat, intracranially), LPS+D (n=18, LPS 0.05 mu g/mu L/rat, intracranially and doxycycline 40 mg/kg, intraperitoneally), LPS+M (n=18, LPS 0.05 mu g/mu L/rat, intracranially and meloxicam 2 mg/kg, intraperitoneally), LPS+Combination (n=18, LPS 0.05 mu g/mu L/rat, intracranially and simultaneously both drug combination) groups. Animals were euthanized at 1, 3 and 6 hours following injections and the brains were removed. Brain SOD, CAT, MDA and MMP-9 levels were determined by ELISA reader. Parameters of LPS groups generally different from Healthy control group. When compared to LPS group, increased SOD level of LPS+D at 3 hours and CAT levels of LPS+M and LPS+D groups were determined (P<0.05) at 3 and 6 hours, respectively. In addition, all treatments statistically significantly (P<0.05) decreased MMP-9 levels at 6 hours. In conclusion, doxycycline and meloxicam may show antioxidant effect via increasing antioxidant enzyme production in the brain; however combined usage of drugs may show more beneficial effect for neuroinflammation.en_US
dc.identifier.citationDik, B., Coskun, D., Bahcivan, E., Er, A. (2019). Doxycycline and Meloxicam Can Treat Neuroinflammation by Increasing Activity of Antioxidant Enzymes in Rat Brain. Pakistan Journal of Pharmaceutical Sciences, 32(1), 391-396.
dc.identifier.endpage396en_US
dc.identifier.issn1011-601Xen_US
dc.identifier.issue1en_US
dc.identifier.pmid30852475en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage391en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37709
dc.identifier.volume32en_US
dc.identifier.wosWOS:000463981600004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDik, Burak.
dc.institutionauthorEr, Ayse.
dc.language.isoenen_US
dc.publisherUNIV KARACHIen_US
dc.relation.ispartofPAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAntioxidantsen_US
dc.subjectdoxycyclineen_US
dc.subjectmeloxicamen_US
dc.subjectneuroinflammationen_US
dc.titleDoxycycline and meloxicam can treat neuroinflammation by increasing activity of antioxidant enzymes in rat brainen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Burak DİK.pdf
Boyut:
364.57 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Full Text Access
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Klinik Öncesi Bilimler/Makale Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu