EFFECTS OF TYLOSIN, TILMICOSIN AND TULATHROMYCIN ON INFLAMMATORY MEDIATORS IN BRONCHOALVEOLAR LAVAGE FLUID OF LIPOPOLYSACCHARIDE-INDUCED LUNG INJURY
Küçük Resim Yok
Tarih
2012
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
AKADEMIAI KIADO ZRT
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The aim of this study was to determine the anti-inflammatory effects of macrolides through kinetic parameters in bronchoalveolar lavage fluid (BALF) of lipopolysaccharide-induced lung injury. Rats were divided into four groups: lipopolysaccharide (LPS), LPS + tylosin, LPS + tilmicosin and LPS + tulathromycin. BALF samples were collected at sampling times. TNF, IL-1 beta, IL-6, IL-10 and 13,14-dihydro-15-keto-prostaglandin F-2 alpha (PGM) and C-reactive protein (CRP) were analysed. Area under the curve (AUC) and maximum plasma concentration (C-max) values of inflammatory mediators were determined by a pharmacokinetic computer programme. When inflammatory mediator concentrations were compared between the LPS group and other groups for each sampling time, the three macrolides had no pronounced depressor effect on cytokine levels, but they depressed PGM and CRP levels. In addition, tylosin and tilmicosin decreased the AUC(0-24) level of TNF, while tilmicosin decreased the AUC(0-24) level of IL-10. Tylosin and tulathromycin decreased the AUC(0-24) of PGM, and all three macrolides decreased the AUC(0-24) of CRP. Especially tylosin and tulathromycin may have more expressed anti-inflammatory effects than tilmicosin, via depressing the production of inflammatory mediators in the lung. The AUC may be used for determining the effects of drugs on inflammation. In this study, the antiinflammatory effects of these antibiotics were evaluated with kinetic parameters as a new and different approach.
Açıklama
Anahtar Kelimeler
Cytokine, macrolides, lipopolysaccharide, anti-inflammatory effects, pharmacokinetic parameters
Kaynak
ACTA VETERINARIA HUNGARICA
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
60
Sayı
4
