EFFECTS OF TYLOSIN, TILMICOSIN AND TULATHROMYCIN ON INFLAMMATORY MEDIATORS IN BRONCHOALVEOLAR LAVAGE FLUID OF LIPOPOLYSACCHARIDE-INDUCED LUNG INJURY

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dc.contributor.authorEr, Ayse
dc.contributor.authorYazar, Enver
dc.date.accessioned2020-03-26T18:25:22Z
dc.date.available2020-03-26T18:25:22Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this study was to determine the anti-inflammatory effects of macrolides through kinetic parameters in bronchoalveolar lavage fluid (BALF) of lipopolysaccharide-induced lung injury. Rats were divided into four groups: lipopolysaccharide (LPS), LPS + tylosin, LPS + tilmicosin and LPS + tulathromycin. BALF samples were collected at sampling times. TNF, IL-1 beta, IL-6, IL-10 and 13,14-dihydro-15-keto-prostaglandin F-2 alpha (PGM) and C-reactive protein (CRP) were analysed. Area under the curve (AUC) and maximum plasma concentration (C-max) values of inflammatory mediators were determined by a pharmacokinetic computer programme. When inflammatory mediator concentrations were compared between the LPS group and other groups for each sampling time, the three macrolides had no pronounced depressor effect on cytokine levels, but they depressed PGM and CRP levels. In addition, tylosin and tilmicosin decreased the AUC(0-24) level of TNF, while tilmicosin decreased the AUC(0-24) level of IL-10. Tylosin and tulathromycin decreased the AUC(0-24) of PGM, and all three macrolides decreased the AUC(0-24) of CRP. Especially tylosin and tulathromycin may have more expressed anti-inflammatory effects than tilmicosin, via depressing the production of inflammatory mediators in the lung. The AUC may be used for determining the effects of drugs on inflammation. In this study, the antiinflammatory effects of these antibiotics were evaluated with kinetic parameters as a new and different approach.en_US
dc.description.sponsorshipSUBAPKSelcuk University [07102001]en_US
dc.description.sponsorshipThis study was a part of a PhD thesis and supported by SUBAPK (07102001).en_US
dc.identifier.doi10.1556/AVet.2012.041en_US
dc.identifier.endpage476en_US
dc.identifier.issn0236-6290en_US
dc.identifier.issn1588-2705en_US
dc.identifier.issue4en_US
dc.identifier.pmid23160029en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage465en_US
dc.identifier.urihttps://dx.doi.org/10.1556/AVet.2012.041
dc.identifier.urihttps://hdl.handle.net/20.500.12395/27997
dc.identifier.volume60en_US
dc.identifier.wosWOS:000311308500006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAKADEMIAI KIADO ZRTen_US
dc.relation.ispartofACTA VETERINARIA HUNGARICAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCytokineen_US
dc.subjectmacrolidesen_US
dc.subjectlipopolysaccharideen_US
dc.subjectanti-inflammatory effectsen_US
dc.subjectpharmacokinetic parametersen_US
dc.titleEFFECTS OF TYLOSIN, TILMICOSIN AND TULATHROMYCIN ON INFLAMMATORY MEDIATORS IN BRONCHOALVEOLAR LAVAGE FLUID OF LIPOPOLYSACCHARIDE-INDUCED LUNG INJURYen_US
dc.typeArticleen_US

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