The relationship between central hemodynamics, morning blood pressure surge, glycemic control and sodium intake in patients with type 2 diabetes and essential hypertension
Küçük Resim Yok
Tarih
2014
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
ELSEVIER IRELAND LTD
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Aims: The current study aimed to investigate the relationship between morning blood pressure surge (MBPS), hemodynamic parameters, glycemic control and 24-h urinary sodium excretion (USE) in patients with type 2 diabetes mellitus (T2DM). Materials and methods: MBPS and central hemodynamic parameters were assessed from ambulatory blood pressure measurements. In addition to routine biochemistry, 24 h urine collection was performed to measure protein, albumin and sodium excretion. Results: There were 146 (38%) patients with T2DM and 238 (72%) patients without T2DM (control group). Patients with T2DM had statistically higher MBPS compared with patients without T2DM (P < 0.0001). In patients with T2DM, MBPS was correlated with HbA1c (rho = 0.311, P < 0.0001), 24 h urinary sodium excretion (USE) (rho = 0.292, P = 0.004) and various hemodynamic parameters. Additionally, regression analysis showed that being male (P = 0.006), the presence of coronary artery disease (P = 0.023), HbA1c (P = 0.012), and 24 h USE (P = 0.001) were independently related with log MBPS in T2DM patients. Conclusion: This study demonstrated that T2DM was an independent risk factor for increased MBPS and MBPS was associated with central hemodynamic parameters. Additionally poor glycemic control and sodium intake were associated with worse MBPS in T2DM. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
Açıklama
Anahtar Kelimeler
Albuminuria, Hba1c, Hemodynamics, Hypertension, Sodium, Surge, Type 2 diabetes
Kaynak
DIABETES RESEARCH AND CLINICAL PRACTICE
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
104
Sayı
3
