Use of intestine-related biomarkers for detecting intestinal epithelial damage in neonatal calves with diarrhea

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dc.contributor.authorOk, Mahmut.
dc.contributor.authorYildiz, Ramazan.
dc.contributor.authorHatipoglu, Fatih.
dc.contributor.authorBaspinar, Nuri.
dc.contributor.authorIder, Merve.
dc.contributor.authorUney, Kamil.
dc.contributor.authorErturk, Alper.
dc.contributor.authorDurgut, Murat K.
dc.contributor.authorTerzi, Funda.
dc.date.accessioned2020-03-26T20:20:36Z
dc.date.available2020-03-26T20:20:36Z
dc.date.issued2020
dc.departmentSelçuk Üniversitesi, Veteriner Fakültesi, Klinik Bilimler Bölümüen_US
dc.description.abstractOBJECTIVE To evaluate the usefulness of intestinal biomarkers in determining the presence of intestinal epithelial damage in neonatal calves with diarrhea caused by 4 etiologic agents. ANIMALS 40 neonatal calves that were healthy (n = 10) or had diarrhea (30). PROCEDURES The study was a cross-sectional study. Results of hematologic analyses and serum concentrations of intestinal fatty acid-binding protein (I-FABP), liver fatty acid-binding protein (L-FABP), trefoil factor 3 (TFF-3), Claudin-3 (CLDN-3), gamma-enteric smooth muscle actin (ACTG2), intestinal alkaline phosphatase (IAP), interleukin-8 (IL-8), platelet-activating factor (PAF), and leptin (LP) were compared among calves grouped according to whether they were healthy (control group; G-1) or had diarrhea caused by K99 Escherichia coli (G-2; n = 10), bovine rota-or coronavirus (G-3; 5 each), or Cryptosporidium spp (G-4; 10). RESULTS Across the 3 time points at which blood samples were obtained and evaluated, the groups of calves with diarrhea generally had markedly higher mean serum concentrations of L-FABP, TFF-3, IAP, IL-8, and LP, compared with the control group. In addition, G-2 also consistently had markedly higher mean serum concentrations of I-FAB and ACTG2 and lower mean serum concentrations of CLDN-3, compared with the control group. CONCLUSIONS AND CLINICAL RELEVANCE Results indicated that degree of intestinal epithelial damage differed among calves grouped by the etiologic agent of diarrhea and that such damage might have been more severe in calves with diarrhea caused by K99 E coli. Additionally, our results indicated that serum concentrations of I-FABP, L-FABP, TFF-3, IAP, IL-8, ACTG2, LP, and CLDN-3 were useful biomarkers of intestinal epithelial damage in calves of the present study.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [1160456]en_US
dc.description.sponsorshipFunded by The Scientific and Technological Research Council of Turkey (TUBITAK; project No. 1160456).en_US
dc.identifier.citationOk, M., Yildiz, R., Hatipoglu, F., Baspinar, N., Ider, M., Üney, K., Ertürk, A., Durgut, M. K., Terzi, F. (2020). Use of Intestine-Related Biomarkers for Detecting Intestinal Epithelial Damage in Neonatal Calves with Diarrhea. American Journal Of Veterinary Research, 81(2), 139-146.
dc.identifier.endpage146en_US
dc.identifier.issn0002-9645en_US
dc.identifier.issn1943-5681en_US
dc.identifier.issue2en_US
dc.identifier.pmid31985285en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage139en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38626
dc.identifier.volume81en_US
dc.identifier.wosWOS:000509740400015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorOk, Mahmut.
dc.institutionauthorHatipoglu, Fatih.
dc.institutionauthorBaspinar, Nuri.
dc.institutionauthorIder, Merve.
dc.institutionauthorUney, Kamil.
dc.institutionauthorDurgut, Murat K.
dc.language.isoenen_US
dc.publisherAMER VETERINARY MEDICAL ASSOCen_US
dc.relation.ispartofAMERICAN JOURNAL OF VETERINARY RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleUse of intestine-related biomarkers for detecting intestinal epithelial damage in neonatal calves with diarrheaen_US
dc.typeArticleen_US

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