The mechanisms of vasorelaxant effect of leptin on isolated rabbit aorta
Küçük Resim Yok
Tarih
2007
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
WILEY
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In the present study, we analysed the effects of leptin on rabbit aorta and the mechanisms underlying these effects. Leptin (10(-12)-10(-9) M) induced concentration-dependent relaxation in intact rabbit aorta rings precontracted with phenylephrine (10(-6) M). Removal of endothelium abolished the effects of leptin. Pretreatment of rings with N-omega-nitro-L-arginine methyl ester (10(-4) M 20 min) or catalase (1200 U/mL 20 min) significantly reduced the relaxant response to leptin when compared with the control group. The incubation of brefeldin A (3.5 x 10(-5) M 90 min), indomethacin (10(-5) M 20 min), tetraethylammonium (10(-4) M 20 min), and glibenclamide (10(-5) M, 20 min) did not affect the leptin-induced vasodilation. These results suggest that leptin relaxes the rabbit aorta. The relaxation is mediated by endothelium-derived nitric oxide and hydrogen peroxide.
Açıklama
Anahtar Kelimeler
H2O2, leptin, nitric oxide, rabbit aorta
Kaynak
FUNDAMENTAL & CLINICAL PHARMACOLOGY
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
21
Sayı
6
