The mechanisms of vasorelaxant effect of leptin on isolated rabbit aorta

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dc.contributor.authorSahin, Ayse Saide
dc.contributor.authorBariskaner, Hulagu
dc.date.accessioned2020-03-26T17:18:35Z
dc.date.available2020-03-26T17:18:35Z
dc.date.issued2007
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn the present study, we analysed the effects of leptin on rabbit aorta and the mechanisms underlying these effects. Leptin (10(-12)-10(-9) M) induced concentration-dependent relaxation in intact rabbit aorta rings precontracted with phenylephrine (10(-6) M). Removal of endothelium abolished the effects of leptin. Pretreatment of rings with N-omega-nitro-L-arginine methyl ester (10(-4) M 20 min) or catalase (1200 U/mL 20 min) significantly reduced the relaxant response to leptin when compared with the control group. The incubation of brefeldin A (3.5 x 10(-5) M 90 min), indomethacin (10(-5) M 20 min), tetraethylammonium (10(-4) M 20 min), and glibenclamide (10(-5) M, 20 min) did not affect the leptin-induced vasodilation. These results suggest that leptin relaxes the rabbit aorta. The relaxation is mediated by endothelium-derived nitric oxide and hydrogen peroxide.en_US
dc.identifier.doi10.1111/j.1472-8206.2007.00541.xen_US
dc.identifier.endpage600en_US
dc.identifier.issn0767-3981en_US
dc.identifier.issn1472-8206en_US
dc.identifier.issue6en_US
dc.identifier.pmid18034660en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage595en_US
dc.identifier.urihttps://dx.doi.org/10.1111/j.1472-8206.2007.00541.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/21694
dc.identifier.volume21en_US
dc.identifier.wosWOS:000251189500004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofFUNDAMENTAL & CLINICAL PHARMACOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectH2O2en_US
dc.subjectleptinen_US
dc.subjectnitric oxideen_US
dc.subjectrabbit aortaen_US
dc.titleThe mechanisms of vasorelaxant effect of leptin on isolated rabbit aortaen_US
dc.typeArticleen_US

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