Relationship between heart-type fatty acid-binding protein levels and coronary artery disease in exercise stress testing: an observational study

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dc.contributor.authorArı, Hatem
dc.contributor.authorTokaç, Mehmet
dc.contributor.authorAlihanoğlu, Yusuf İzzettin
dc.contributor.authorKıyıcı, Aysel
dc.contributor.authorKayrak, Mehmet
dc.contributor.authorArı, Mehtap
dc.contributor.authorSönmez, Osman
dc.date.accessioned2020-03-26T18:15:56Z
dc.date.available2020-03-26T18:15:56Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: Although, there has been great improvement on the diagnosis and early treatment of acute coronary syndromes, especially in terms of myocardial damage biochemical markers, we do not have a specific marker yet, for using the diagnosis of stable coronary artery disease (CAD). This study aimed to evaluate the relationship between CAD and the changes of heart-type fatty acid binding protein (H-FABP) levels before and after exercise stress testing (EST). Methods: A total of 47 patients were enrolled in this observational study. Of 47 patients, 21 had normal coronary anatomy; the remaining 26 patients had coronary lesions over 70% in at least one major coronary artery. All patients performed EST. Along with this, H-FABP levels before EST and at peak exercise, 1(st) hour, 3(rd) hour (3h), were measured in all patients. Differences among the measurements were evaluated through the Friedman test and Wilcoxon test, and the Bonferroni correction was applied to determine which measurement caused the difference. Results: Contrary to expectations, the means of the H-FABP values measured at particular intervals for each group tended to decline from the basal level to the 3h level. When the difference between the 3h measurement and the basal level was compared in each group, the decreasing was statistically significant in both groups (p<0.05). A statistically significant decrease at the 3h measurement compared to the basal level in the CAD group was more apparent than in the control group (2.790 +/- 2.569ng/ml vs. 0.837 +/- 2.070ng/ml, p=0.009). Conclusion: We found that H-FABP levels did not increase during EST and contrary to expectation, were inclined to decrease. We thought that decreasing H-FABP levels likely resulted from exercise-induced proteinuria. (Anadolu Kardiyol Berg 2011; 11: 685-91)en_US
dc.description.sponsorshipSelcuk UniversitySelcuk Universityen_US
dc.description.sponsorshipFinancial support of the present study was provided by the Scientific Investigation and Project Foundation of Selcuk University.en_US
dc.identifier.doi10.5152/akd.2011.189en_US
dc.identifier.endpage691en_US
dc.identifier.issn2149-2263en_US
dc.identifier.issn2149-2271en_US
dc.identifier.issue8en_US
dc.identifier.pmid22037103en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage685en_US
dc.identifier.urihttps://dx.doi.org/10.5152/akd.2011.189
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26779
dc.identifier.volume11en_US
dc.identifier.wosWOS:000298576700006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTURKISH SOC CARDIOLOGYen_US
dc.relation.ispartofANATOLIAN JOURNAL OF CARDIOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCoronary artery diseaseen_US
dc.subjectheart-type fatty acid binding proteinen_US
dc.subjectexercise stress testingen_US
dc.titleRelationship between heart-type fatty acid-binding protein levels and coronary artery disease in exercise stress testing: an observational studyen_US
dc.typeArticleen_US

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