What Should Be the Ideal Time for Ischemic Preconditioning in a Laparoscopic Rat Model?

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dc.contributor.authorArioz, Dağıstan Tolga
dc.contributor.authorPolat, Coşkun
dc.contributor.authorTokyol, Çiğdem
dc.contributor.authorKahraman, Ahmet
dc.contributor.authorYılmaz, Sezgin
dc.contributor.authorDemirel, Reha
dc.contributor.authorSaylan, Arif
dc.contributor.authorYılmazer, Mehmet
dc.contributor.authorTekin, Ahmet
dc.date.accessioned2020-03-26T17:41:12Z
dc.date.available2020-03-26T17:41:12Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: Pneumoperitoneum (Pp) induces an ischemia and reperfusion (I/R) injury as a result of released oxidative stress markers. Ischemic preconditioning (IP) is one of the used methods to reduce the harmful effects of Pp, which is a mechanism for reducing organ I/R injury by a brief period of organ ischemia. The aim of this study was to investigate the ideal time for IP in the laparoscopic model. Methods: Thirty-two rats were assigned into four groups: group 1 (control, n = 8) was subjected to a sham operation. Group 2 (5-minutes IP, n = 8) was subjected to 5 minutes of Pp with 15 mm Hg of pressure followed immediately by 5 minutes of deflation, and after that, 60 minutes of Pp with 15 mm Hg, followed by 60 minutes of deflation. Group 3 (10-minutes IP, n = 8) was subjected to 10 minutes of Pp and 10 minutes of deflation. Group 4 (Pp only, n = 8) was subjected to 60 minutes of Pp with 15 mm Hg of pressure, followed by 60 minutes of deflation. At the end of the experiment, plasma malondialdehyde (MDA) values, the oxidative stress marker, and plasma-reduced glutathione (GSH) levels, the marker showing antioxidant activity, were determined. Results: Highest plasma MDA values were in group 4 (Pp only), followed by groups 2 and 3 and group 1 (P = 0.181). In addition, IP groups had almost the same values for MDA. Plasma GSH levels in the control group were significantly higher than those in the IP groups and the Pp-only group (P < 0.001). Similarly, as in MDA levels, no difference was found between plasma GSH levels of the IP 5-minutes and IP 10-minutes groups. Conclusions: Five minutes of the IP model may be as reliable as 10 minutes of the IP model. In that case, 5 minutes of IP can be more suitable in reducing I/R injury in laparoscopy.en_US
dc.identifier.citationTekin, A., Yılmaz, M., Saylan, A., Demirel, R., Yılmaz, S., Kahraman, A., Tokyol, Ç., Polat, C., Arioz, Dağıstan, T., (2009). What Should Be the Ideal Time for Ischemic Preconditioning in a Laparoscopic Rat Model?. Journal of Laparoendoscopic & Advanced Surgical Techniques, 19(2), 141-147. Doi: 10.1089/lap.2008.0264
dc.identifier.doi10.1089/lap.2008.0264en_US
dc.identifier.endpage147en_US
dc.identifier.issn1092-6429en_US
dc.identifier.issue2en_US
dc.identifier.pmid19260787en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage141en_US
dc.identifier.urihttps://dx.doi.org/10.1089/lap.2008.0264
dc.identifier.urihttps://hdl.handle.net/20.500.12395/24024
dc.identifier.volume19en_US
dc.identifier.wosWOS:000265086900004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTekin, Ahmet
dc.language.isoenen_US
dc.publisherMary Ann Liebert Incen_US
dc.relation.ispartofJournal of Laparoendoscopic & Advanced Surgical Techniquesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleWhat Should Be the Ideal Time for Ischemic Preconditioning in a Laparoscopic Rat Model?en_US
dc.typeArticleen_US

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