Production of a new platform based calixarene nanofiber for controlled release of the drugs

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dc.contributor.authorCağıl, Esra Maltaş
dc.contributor.authorHameed, Othman
dc.contributor.authorÖzcan, Fatih
dc.date.accessioned2020-03-26T20:19:10Z
dc.date.available2020-03-26T20:19:10Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this study is to develop an electrospun calixarene nanofiber based calixarene for controlled release of hydrophobic drugs. To accomplish this, we have synthesized 5,17-bis[Methyl-N-Methyltranylate]-25,26,27,28-tetrahydroxycalix[4]arene (Compound 3) of which nanofiber (F-14) was produced by electrospinning. The fabricated multilayered electrospun nanofiber was first characterized in terms of morphology and then drug loading and release kinetics were studied in different physiological pH. For this purpose, we have selected two fluorescent drugs which are thiabendazole (Tbz) and donepezil (Dnp) as model drugs to show the usage of the synthesized nanofiber in drug delivery system. Drug loading and release kinetics were monitored by using fluorescence spectroscopy. According to the results, maximum amount of loaded Dnp onto nanofiber was found to be as 30.529 mu g in 20 mM Tris buffer, pH 7.4 end of 120 min. Data showed that loading amount of Tbz onto the nanofiber was measured to be as 1.688 mu g to the 2.25 cm(2) of surface in 20 mM of Tris buffer, pH 7.4 at the end of 120 min. While max release of Dnp from nanofiber was also 9.720 mu g at pH 2.2, that of Tbz from nanofiber was 0.243 mu g at pH 7.4 at the end of 90 min. Drug loading to nanofibers was clarified by SEM, TEM, EDX and FT-IR analysis.en_US
dc.description.sponsorshipResearch Foundation of Selcuk University (BAP)Selcuk University [:18401041]en_US
dc.description.sponsorshipWe would like to thank The Research Foundation of Selcuk University (BAP) for financial support of this work (Grant No:18401041).en_US
dc.identifier.citationÇağıl, E. M., Hameed, O., Özcan, F. (2019). Production Of A New Platform Based Calixarene Nanofiber For Controlled Release Of The Drugs. Materials Science And Engineering: C, 100, 466-474.
dc.identifier.doi10.1016/j.msec.2019.03.038en_US
dc.identifier.endpage474en_US
dc.identifier.issn0928-4931en_US
dc.identifier.issn1873-0191en_US
dc.identifier.pmid30948082en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage466en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.msec.2019.03.038
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38127
dc.identifier.volume100en_US
dc.identifier.wosWOS:000466059700045en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÇağıl, Esra Maltaş
dc.institutionauthorHameed, Othman
dc.institutionauthorÖzcan, Fatih
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofMATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectThiabendazoleen_US
dc.subjectDonepezilen_US
dc.subjectNanofiberen_US
dc.subjectCalixareneen_US
dc.subjectControlled releaseen_US
dc.subjectPharmaceuticsen_US
dc.titleProduction of a new platform based calixarene nanofiber for controlled release of the drugsen_US
dc.typeArticleen_US

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