Protective effect of distillated Nerium oleander on heart of type 2 diabetic rats
Küçük Resim Yok
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
COMENIUS UNIV
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
OBJECTIVES: The current study aims to investigate the possible role of NO distillate either for therapeutic or for protective potential in diabetic cardiomyopathy. BACKGROUND: Protective and restorative effects of distillated Nerium oleander (NO) on the diabetes-induced electrophysiological and structural alterations were investigated. METHODS: Type 2 diabetes was induced by combination of single dose streptozotocin injection and high fat diet for four weeks. Experimental groups were designed as follows: control, diabetic, restorative-NO treated diabetic and protective-NO treated diabetic. Intracellular action potentials (AP) and contractile activities were measured form left ventricular papillary muscle strips as well as histopathological examination of heart tissue and biochemical examinations of serum were performed. RESULTS: Type 2 diabetes induced AP prolongation was prevented with both ways of NO treatments. Moreover, treatments produced nearly complete restorations of diabetes-induced depressed amplitude and altered kinetics of contractile activities. In parallel to electrophysiological parameters, both histopathological and biochemical results indicates the NO induced beneficial effects on the diabetes related alterations. CONCLUSION: Distillated Nerium oleander (NO) can be a highly potential therapeutic or preventive agent on the diabetes induced excitation-contraction coupling alterations (Tab. 3, Fig. 3, Ref. 23). Text in PDF www.elis.sk.
Açıklama
Anahtar Kelimeler
type II diabetes, cardiomyopathy, Nerium oleander, heart, electrophysiology
Kaynak
BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
116
Sayı
7
