Protective effect of distillated Nerium oleander on heart of type 2 diabetic rats

Basit Öğe Kaydı
dc.contributor.authorAyaz, M.
dc.contributor.authorBaba, Fevzi
dc.contributor.authorAkgün, N.
dc.contributor.authorBaş, Ahmet Levent
dc.contributor.authorÜney, Kamil
dc.contributor.authorDik, Burak
dc.date.accessioned2020-03-26T19:06:48Z
dc.date.available2020-03-26T19:06:48Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractOBJECTIVES: The current study aims to investigate the possible role of NO distillate either for therapeutic or for protective potential in diabetic cardiomyopathy. BACKGROUND: Protective and restorative effects of distillated Nerium oleander (NO) on the diabetes-induced electrophysiological and structural alterations were investigated. METHODS: Type 2 diabetes was induced by combination of single dose streptozotocin injection and high fat diet for four weeks. Experimental groups were designed as follows: control, diabetic, restorative-NO treated diabetic and protective-NO treated diabetic. Intracellular action potentials (AP) and contractile activities were measured form left ventricular papillary muscle strips as well as histopathological examination of heart tissue and biochemical examinations of serum were performed. RESULTS: Type 2 diabetes induced AP prolongation was prevented with both ways of NO treatments. Moreover, treatments produced nearly complete restorations of diabetes-induced depressed amplitude and altered kinetics of contractile activities. In parallel to electrophysiological parameters, both histopathological and biochemical results indicates the NO induced beneficial effects on the diabetes related alterations. CONCLUSION: Distillated Nerium oleander (NO) can be a highly potential therapeutic or preventive agent on the diabetes induced excitation-contraction coupling alterations (Tab. 3, Fig. 3, Ref. 23). Text in PDF www.elis.sk.en_US
dc.description.sponsorshipSelcuk UniversitySelcuk University [10202017, 11401159]en_US
dc.description.sponsorshipThis scientific project was approved and supported by Scientific Research and Project Coordinator of Selcuk University (Fund number: 10202017 and 11401159). Part of this scientific research covers the MSc thesis of third author.en_US
dc.identifier.doi10.4149/BLL_2015_085en_US
dc.identifier.endpage456en_US
dc.identifier.issn0006-9248en_US
dc.identifier.issn1336-0345en_US
dc.identifier.issue7en_US
dc.identifier.pmid26286249en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage451en_US
dc.identifier.urihttps://dx.doi.org/10.4149/BLL_2015_085
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32472
dc.identifier.volume116en_US
dc.identifier.wosWOS:000359391500011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCOMENIUS UNIVen_US
dc.relation.ispartofBRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjecttype II diabetesen_US
dc.subjectcardiomyopathyen_US
dc.subjectNerium oleanderen_US
dc.subjecthearten_US
dc.subjectelectrophysiologyen_US
dc.titleProtective effect of distillated Nerium oleander on heart of type 2 diabetic ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu