eNOS gene polymorphisms in paraffin-embedded tissues of prostate cancer patients

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dc.contributor.authorPolat, Fikriye
dc.contributor.authorTuraclar, Nesrin
dc.contributor.authorYilmaz, Meral
dc.contributor.authorBingol, Gunsel
dc.contributor.authorCingilli Vural, Hasibe
dc.date.accessioned2020-03-26T19:23:58Z
dc.date.available2020-03-26T19:23:58Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground/aim: The purpose of the present study was to investigate whether endothelial nitric oxide synthase (eNOS) gene polymorphisms play a role in prostate cancer (PCa). Materials and methods: We examined three eNOS gene polymorphisms (T-786C promoter region, G894T, and Intron 4 VNTR 4a/b) at extracted DNAs from 50 formalin-fixed paraffin-embedded tissues of PCa patients. For the controls, blood samples obtained from 50 healthy men were studied. Genotyping of molecular variants was performed by PCR-RFLP technique. Results: We found that the TC genotype of the T-786C polymorphism was associated with PCa risk (OR: 3.325, CI: 1.350-8.188, P = 0.008). The eNOS G894T polymorphism was also associated with PCa. The frequency of the 894T allele was significantly higher in PCa patients. No association was identified between intron 4 VNTR polymorphism and PCa. Conclusion: We found significant differences in genotypic and allelic frequencies between PCa patients and controls for eNOS T-786C and G894T polymorphisms. The presence of the T-786C genotype and 894T allele in carriers increased the risk of PCa. No association was found between intron 4 VNTR polymorphism and PCa patients.en_US
dc.description.sponsorshipScientific Research Unit, Kocaeli UniversityKocaeli University [2013/025]en_US
dc.description.sponsorshipWe thank the Molecular Biology Research Laboratory of the Department of Biology at Kocaeli University for providing technical support. This investigation was supported by the Scientific Research Unit, Kocaeli University (2013/025).en_US
dc.identifier.doi10.3906/sag-1411-8en_US
dc.identifier.endpage679en_US
dc.identifier.issn1300-0144en_US
dc.identifier.issn1303-6165en_US
dc.identifier.issue3en_US
dc.identifier.pmid27513240en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage673en_US
dc.identifier.urihttps://dx.doi.org/10.3906/sag-1411-8
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33547
dc.identifier.volume46en_US
dc.identifier.wosWOS:000374327500013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEYen_US
dc.relation.ispartofTURKISH JOURNAL OF MEDICAL SCIENCESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectPolymorphismen_US
dc.subjectprostate canceren_US
dc.subjecteNOSen_US
dc.titleeNOS gene polymorphisms in paraffin-embedded tissues of prostate cancer patientsen_US
dc.typeArticleen_US

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