Selenium supplementation prevents lipid peroxidation caused by arduous exercise in rat brain tissue
Küçük Resim Yok
Tarih
2011
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
COMENIUS UNIV
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: The objective of the present study is to examine how selenium supplementation affects lipid peroxidation in the brain tissue of rats subjected to acute swimming exercise. Methods: The study was carried out on 32 Spraque-Dawley adult male rats, which were allocated equally to four groups, namely general control (Group 1), selenium-supplemented control (0.6 mg/kg/day sodium selenite) (Group 2), swimming control (Group 3), and selenium-supplemented swimming group (6 mg/kg/day sodium selenite) (Group 4). Selenium supplementations were carried out by intraperitoneal (i.p.) route for four weeks. At the end of supplementation, animals in groups 3 and 4 were subjected to acute swimming. Brain tissue samples were collected from decapitated animals to determine malondialdehyde (MDA) levels using a spectrophotometer according to "Schimadzu-1601, Japan" Uchiyama and Mihara and GSH levels using a spectrophotometer according to Ellmann. Results: The highest MDA values in the brain tissue were obtained in Group 3 (p<0.001). MDA values in Group 4 were higher than those in Groups 1 and 2 (p<0.001). Brain tissue MDA values in Groups 1 and 2 did not differ. Group 4 had the highest brain GSH levels (p<0.001). Brain tissue glutathione (GSH) levels in Group 3 were higher than those in Groups 1 and 2 (p<0.001). Conclusion: Results of the study indicate that acute swimming exercise in rats increased the lipid peroxidation in the brain tissue of rats, while selenium supplementation prevented the free-radical formation by enhancing the antioxidant activity (Tab. 1, Ref. 24). Full Text in free PDF www.bmj.sk.
Açıklama
Anahtar Kelimeler
selenium, exercise, brain, lipid peroxidation, rat
Kaynak
BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
112
Sayı
6
