Selenium supplementation prevents lipid peroxidation caused by arduous exercise in rat brain tissue

Basit Öğe Kaydı
dc.contributor.authorAkil, Mustafa
dc.contributor.authorBiçer, Mürsel
dc.contributor.authorMenevşe, Esma
dc.contributor.authorBaltacı, Abdulkerim Kasım
dc.contributor.authorMoğulkoç, Rasim
dc.date.accessioned2020-03-26T18:16:05Z
dc.date.available2020-03-26T18:16:05Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: The objective of the present study is to examine how selenium supplementation affects lipid peroxidation in the brain tissue of rats subjected to acute swimming exercise. Methods: The study was carried out on 32 Spraque-Dawley adult male rats, which were allocated equally to four groups, namely general control (Group 1), selenium-supplemented control (0.6 mg/kg/day sodium selenite) (Group 2), swimming control (Group 3), and selenium-supplemented swimming group (6 mg/kg/day sodium selenite) (Group 4). Selenium supplementations were carried out by intraperitoneal (i.p.) route for four weeks. At the end of supplementation, animals in groups 3 and 4 were subjected to acute swimming. Brain tissue samples were collected from decapitated animals to determine malondialdehyde (MDA) levels using a spectrophotometer according to "Schimadzu-1601, Japan" Uchiyama and Mihara and GSH levels using a spectrophotometer according to Ellmann. Results: The highest MDA values in the brain tissue were obtained in Group 3 (p<0.001). MDA values in Group 4 were higher than those in Groups 1 and 2 (p<0.001). Brain tissue MDA values in Groups 1 and 2 did not differ. Group 4 had the highest brain GSH levels (p<0.001). Brain tissue glutathione (GSH) levels in Group 3 were higher than those in Groups 1 and 2 (p<0.001). Conclusion: Results of the study indicate that acute swimming exercise in rats increased the lipid peroxidation in the brain tissue of rats, while selenium supplementation prevented the free-radical formation by enhancing the antioxidant activity (Tab. 1, Ref. 24). Full Text in free PDF www.bmj.sk.en_US
dc.identifier.endpage317en_US
dc.identifier.issn0006-9248en_US
dc.identifier.issue6en_US
dc.identifier.pmid21692404en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage314en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26808
dc.identifier.volume112en_US
dc.identifier.wosWOS:000291378700002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCOMENIUS UNIVen_US
dc.relation.ispartofBRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectseleniumen_US
dc.subjectexerciseen_US
dc.subjectbrainen_US
dc.subjectlipid peroxidationen_US
dc.subjectraten_US
dc.titleSelenium supplementation prevents lipid peroxidation caused by arduous exercise in rat brain tissueen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu