Association Between Exaggerated Blood Pressure Response to Exercise and Serum Asymmetric Dimethylarginine Levels

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dc.contributor.authorKayrak, Mehmet
dc.contributor.authorBacaksız, Ahmet
dc.contributor.authorVatankulu, Mehmet Akif
dc.contributor.authorAyhan, Selim S.
dc.contributor.authorTaner, Alparslan
dc.contributor.authorÜnlü, Ali
dc.contributor.authorYazıcı, Mehmet
dc.contributor.authorÜlgen, Mehmet S.
dc.date.accessioned2020-03-26T17:47:09Z
dc.date.available2020-03-26T17:47:09Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: The exaggerated blood pressure response to exercise (EBPR) is an independent predictor of hypertension. Asymmetric dimethylarginine (ADMA) is an endogenous nitric oxide inhibitor and higher plasma levels of ADMA are related to increased cardiovascular risk. The aim of this study is to identify the relationship between ADMA and EBPR. Methods and Results: A total of 66 patients (36 with EBPR and 30 as controls) were enrolled in the study. EBPR is defined as blood pressure (BP) measurements >= 200/100 mmHg during the treadmill test. All the subjects underwent 24-h ambulatory BP monitoring. L-arginine and ADMA levels were measured using a high performance lipid chromatography technique. The serum ADMA levels were increased in the EBPR group compared to the healthy controls (4.0 +/- 1.4 vs 2.6 +/- 1.1 mu mol/L respectively, P=0.001), but L-arginine levels were similar in the 2 groups (P=0.19). The serum ADMA levels were detected as an independent predictor of EBPR (odds ratio 2.28; 95% confidence interval 1.22-4.24; P=0.002). Conclusions: Serum ADMA levels might play a role in EBPR to exercise.en_US
dc.identifier.citationKayrak, M., Bacaksız, A., Vatankulu, M. A., Ayhan, S. S., Taner, A., Ünlü, A., Yazıcı, M., Ülgen, M. S.,(2010). Association Between Exaggerated Blood Pressure Response to Exercise and Serum Asymmetric Dimethylarginine Levels. Circulation Journal, (74), 1135-1141. Doi: 10.1253/circj.CJ-09-0419
dc.identifier.doi10.1253/circj.CJ-09-0419en_US
dc.identifier.endpage1141en_US
dc.identifier.issn1346-9843en_US
dc.identifier.issn1347-4820en_US
dc.identifier.pmid20453387en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1135en_US
dc.identifier.urihttps://dx.doi.org/10.1253/circj.CJ-09-0419
dc.identifier.urihttps://hdl.handle.net/20.500.12395/24634
dc.identifier.volume74en_US
dc.identifier.wosWOS:000278211900020en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTaner, Alparslan
dc.institutionauthorÜnlü, Ali
dc.language.isoenen_US
dc.publisherJapanese Circulation Socen_US
dc.relation.ispartofCirculation Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectADMAen_US
dc.subjectCardiovascular risken_US
dc.subjectExaggerated blood pressure response to exerciseen_US
dc.subjectHypertensionen_US
dc.titleAssociation Between Exaggerated Blood Pressure Response to Exercise and Serum Asymmetric Dimethylarginine Levelsen_US
dc.typeArticleen_US

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