The role of K+ ions on the response to carbachol of calf coronary artery and cardiac vein during cooling
Yükleniyor...
Dosyalar
Tarih
2001
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
PROUS SCIENCE, SA
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The role of K+ ions on the vasoconstrictions induced by carbachol during cooling (28 degreesC) in the endothelium of a denuded calf coronary artery and cardiac vein (noncutaneous vessel) was studied. Carbachol (10(-9) - 3 X 10(-4)M) induced concentration-dependent contractions at both 37 degreesC and 28 degreesC. The sensitivity, but not the maximal response, of carbachol (10(-9) - 3 x 10(-4) M) was significantly lower at 28 degreesC than at 37 degreesC. Cooling to 28 degreesC after treatment with tetraethylammonium (TEA, 10(-3) M) or ouabain (10(-5) M), or after incubation in K+-free medium, increased the sensitivity to carbachol in both preparations. The results suggest a role for K+ ions in the cooling-induced changes of noncutaneous vessels. (C) 2001 Prous Science. All rights reserved.
Açıklama
Anahtar Kelimeler
cardiac vein, cooling, coronary artery, K+ ions
Kaynak
METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY
WoS Q Değeri
Q4
Scopus Q Değeri
N/A
Cilt
23
Sayı
5
