The role of K+ ions on the response to carbachol of calf coronary artery and cardiac vein during cooling
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Date
2001
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
PROUS SCIENCE, SA
Access Rights
info:eu-repo/semantics/openAccess
Abstract
The role of K+ ions on the vasoconstrictions induced by carbachol during cooling (28 degreesC) in the endothelium of a denuded calf coronary artery and cardiac vein (noncutaneous vessel) was studied. Carbachol (10(-9) - 3 X 10(-4)M) induced concentration-dependent contractions at both 37 degreesC and 28 degreesC. The sensitivity, but not the maximal response, of carbachol (10(-9) - 3 x 10(-4) M) was significantly lower at 28 degreesC than at 37 degreesC. Cooling to 28 degreesC after treatment with tetraethylammonium (TEA, 10(-3) M) or ouabain (10(-5) M), or after incubation in K+-free medium, increased the sensitivity to carbachol in both preparations. The results suggest a role for K+ ions in the cooling-induced changes of noncutaneous vessels. (C) 2001 Prous Science. All rights reserved.
Description
Keywords
cardiac vein, cooling, coronary artery, K+ ions
Journal or Series
METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY
WoS Q Value
Q4
Scopus Q Value
N/A
Volume
23
Issue
5
