The role of K+ ions on the response to carbachol of calf coronary artery and cardiac vein during cooling

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dc.contributor.authorAtalik, KE
dc.contributor.authorSahin, AS
dc.contributor.authorUlusoy, HB
dc.contributor.authorDogan, N
dc.date.accessioned2020-03-26T16:37:30Z
dc.date.available2020-03-26T16:37:30Z
dc.date.issued2001
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe role of K+ ions on the vasoconstrictions induced by carbachol during cooling (28 degreesC) in the endothelium of a denuded calf coronary artery and cardiac vein (noncutaneous vessel) was studied. Carbachol (10(-9) - 3 X 10(-4)M) induced concentration-dependent contractions at both 37 degreesC and 28 degreesC. The sensitivity, but not the maximal response, of carbachol (10(-9) - 3 x 10(-4) M) was significantly lower at 28 degreesC than at 37 degreesC. Cooling to 28 degreesC after treatment with tetraethylammonium (TEA, 10(-3) M) or ouabain (10(-5) M), or after incubation in K+-free medium, increased the sensitivity to carbachol in both preparations. The results suggest a role for K+ ions in the cooling-induced changes of noncutaneous vessels. (C) 2001 Prous Science. All rights reserved.en_US
dc.identifier.doi10.1358/mf.2001.23.5.662118en_US
dc.identifier.endpage234en_US
dc.identifier.issn0379-0355en_US
dc.identifier.issue5en_US
dc.identifier.pmid11712641en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage231en_US
dc.identifier.urihttps://dx.doi.org/10.1358/mf.2001.23.5.662118
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17635
dc.identifier.volume23en_US
dc.identifier.wosWOS:000171860000004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPROUS SCIENCE, SAen_US
dc.relation.ispartofMETHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcardiac veinen_US
dc.subjectcoolingen_US
dc.subjectcoronary arteryen_US
dc.subjectK+ ionsen_US
dc.titleThe role of K+ ions on the response to carbachol of calf coronary artery and cardiac vein during coolingen_US
dc.typeArticleen_US

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