Relationship between race and outcome in asian, black, and caucasian patients with spontaneous intracerebral hemorrhage: data from the virtual international stroke trials archive and efficacy of nitric oxide in stroke trial
Yükleniyor...
Dosyalar
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
SAGE PUBLICATIONS LTD
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background and purpose Although poor prognosis after intracerebral hemorrhage relates to risk factors and hematoma characteristics, there is limited evidence for the effect of race-ethnicity. Methods Data from 1011 patients with intracerebral hemorrhage enrolled into hyperacute trials and randomized to control were obtained from the Virtual International Stroke Trials Archive and Efficacy of Nitric Oxide in Stroke Trial. Clinical characteristics and functional outcome were compared among three racial groups - Asians, Blacks, and Caucasians. Results The majority of patients were Caucasian (78.1%) followed by Asians (14.5%) and Blacks (5.5%). At baseline, Caucasians were older and had larger hematoma volumes; Blacks had lower Glasgow Coma Scale and higher systolic blood pressure (all p<0.05). Although the primary outcome of modified Rankin Scale did not differ at 90 days (p=0.14), there were significant differences in mortality (p<0.0001) and quality of life (EQ-5D p<0.0001; EQ-VAS p 0.015). In test of multiple comparisons, Caucasians were more likely to die (p=0.0003) and had worse quality of life (EQ-5D p=0.003; EQ-VAS p<0.0001) as compared to Asians. Conclusion Race-ethnicity appears to explain some of the variation in clinical characteristics and outcomes after acute intracerebral hemorrhage. Factors that explain this variation need to be identified.
Açıklama
Anahtar Kelimeler
Intracerebral hemorrhage, ethnicity, race, outcome, randomized controlled trial, Virtual International Stroke Trials Archive, Efficacy of Nitric Oxide in Stroke
Kaynak
INTERNATIONAL JOURNAL OF STROKE
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
13
Sayı
4
Künye
Krishnan, K., Beishon, L., Berge, E., Christensen, H., Dineen, R. A., Ozturk, S., Sprigg, N., Wardlaw, J. M., Bath, P. M. (2018). Relationship Between Race and Outcome in Asian, Black, and Caucasian Patients with Spontaneous Intracerebral Hemorrhage: Data from The Virtual International Stroke Trials Archive and Efficacy of Nitric Oxide in Stroke Trial. International Journal of Stroke, 13(4), 362-373.
