Relationship between race and outcome in asian, black, and caucasian patients with spontaneous intracerebral hemorrhage: data from the virtual international stroke trials archive and efficacy of nitric oxide in stroke trial

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dc.contributor.authorKrishnan, Kailash.
dc.contributor.authorBeishon, Lucy.
dc.contributor.authorBerge, Eivind.
dc.contributor.authorChristensen, Hanne.
dc.contributor.authorDineen, Robert A.
dc.contributor.authorOzturk, Serefnur.
dc.contributor.authorSprigg, Nikola.
dc.contributor.authorWardlaw, Joanna M.
dc.contributor.authorBath, Philip M.
dc.date.accessioned2020-03-26T19:55:29Z
dc.date.available2020-03-26T19:55:29Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü.en_US
dc.description.abstractBackground and purpose Although poor prognosis after intracerebral hemorrhage relates to risk factors and hematoma characteristics, there is limited evidence for the effect of race-ethnicity. Methods Data from 1011 patients with intracerebral hemorrhage enrolled into hyperacute trials and randomized to control were obtained from the Virtual International Stroke Trials Archive and Efficacy of Nitric Oxide in Stroke Trial. Clinical characteristics and functional outcome were compared among three racial groups - Asians, Blacks, and Caucasians. Results The majority of patients were Caucasian (78.1%) followed by Asians (14.5%) and Blacks (5.5%). At baseline, Caucasians were older and had larger hematoma volumes; Blacks had lower Glasgow Coma Scale and higher systolic blood pressure (all p<0.05). Although the primary outcome of modified Rankin Scale did not differ at 90 days (p=0.14), there were significant differences in mortality (p<0.0001) and quality of life (EQ-5D p<0.0001; EQ-VAS p 0.015). In test of multiple comparisons, Caucasians were more likely to die (p=0.0003) and had worse quality of life (EQ-5D p=0.003; EQ-VAS p<0.0001) as compared to Asians. Conclusion Race-ethnicity appears to explain some of the variation in clinical characteristics and outcomes after acute intracerebral hemorrhage. Factors that explain this variation need to be identified.en_US
dc.description.sponsorshipMedical Research CouncilMedical Research Council UK (MRC) [G0501797]; University of Nottinghamen_US
dc.description.sponsorshipThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Medical Research Council [grant number G0501797]; and the University of Nottingham.en_US
dc.identifier.citationKrishnan, K., Beishon, L., Berge, E., Christensen, H., Dineen, R. A., Ozturk, S., Sprigg, N., Wardlaw, J. M., Bath, P. M. (2018). Relationship Between Race and Outcome in Asian, Black, and Caucasian Patients with Spontaneous Intracerebral Hemorrhage: Data from The Virtual International Stroke Trials Archive and Efficacy of Nitric Oxide in Stroke Trial. International Journal of Stroke, 13(4), 362-373.
dc.identifier.doi10.1177/1747493017744463en_US
dc.identifier.endpage373en_US
dc.identifier.issn1747-4930en_US
dc.identifier.issn1747-4949en_US
dc.identifier.issue4en_US
dc.identifier.pmid29165060en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage362en_US
dc.identifier.urihttps://dx.doi.org/10.1177/1747493017744463
dc.identifier.urihttps://hdl.handle.net/20.500.12395/36915
dc.identifier.volume13en_US
dc.identifier.wosWOS:000432079700007en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorOzturk, Serefnur.
dc.language.isoenen_US
dc.publisherSAGE PUBLICATIONS LTDen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF STROKEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectIntracerebral hemorrhageen_US
dc.subjectethnicityen_US
dc.subjectraceen_US
dc.subjectoutcomeen_US
dc.subjectrandomized controlled trialen_US
dc.subjectVirtual International Stroke Trials Archiveen_US
dc.subjectEfficacy of Nitric Oxide in Strokeen_US
dc.titleRelationship between race and outcome in asian, black, and caucasian patients with spontaneous intracerebral hemorrhage: data from the virtual international stroke trials archive and efficacy of nitric oxide in stroke trialen_US
dc.typeArticleen_US

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