Serum Asymmetric Dimethylarginine Levels in Normotensive Obese Individuals

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dc.contributor.authorKoç, Fatih
dc.contributor.authorTokaç, Mehmet
dc.contributor.authorErdem, Sami
dc.contributor.authorKaya, Coşkun
dc.contributor.authorÜnlü, Ali
dc.contributor.authorKarabağ, Turgut
dc.contributor.authorVatankulu, Mehmet Akif
dc.contributor.authorDemir, Kenan
dc.contributor.authorAyhan, Selim
dc.contributor.authorKaya, Ahmet
dc.date.accessioned2020-03-26T18:04:59Z
dc.date.available2020-03-26T18:04:59Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: Obesity is associated with an increased risk of developing insulin resistance, hyperinsulinemia, glucose intolerance, dyslipidemia, hypertension, premature atherosclerosis, and coronary artery disease. This study is designed to compare serum asymmetric dimethylarginine (ADMA) levels between obese individuals and controls. Material/Methods: Fifty volunteers, 30 obese (13 men; mean age, 40 +/- 11 years) and 20 healthy controls (13 men; mean age, 44 +/- 10 years) were enrolled to this study. Measurement of ADMA was accomplished by high performance liquid chromatography. Results: The mean body mass index of the obese group was significantly higher than that of the control group (35 +/- 4 vs 26 +/- 3 kg/m(2); P=.001). The mean waist circumference of the obese subjects was also significantly higher compared with controls (111 +/- 11 vs 93 +/- 10 cm; P=.001). No significant difference was found concerning age, sex, blood pressures, and biochemistry parameters. Serum ADMA levels were significantly higher in obese individuals compared with healthy controls (5.4 +/- 3.3 vs 3.1 +/- 1.8 mu mol/L; P=.006). A weak but significant correlation was identified between serum ADMA concentration and the waist circumference (r=0.282, P=.047). Conclusions: The results of the present study demonstrated that serum ADMA levels of normotensive obese individuals were significantly higher than healthy controls. Increased ADMA concentrations observed only in the obese group were deemed to be important regarding the development future of cardiovascular disease in the future.en_US
dc.identifier.citationKoç, F., Tokaç, M., Erdem, S., Kaya, C., Ünlü, A., Karabağ, T., Vatankulu, M. A., Demir, K., Ayhan, S., Kaya, A., (2010). Serum Asymmetric Dimethylarginine Levels in Normotensive Obese Individuals. Medical Science Monitor, 16(11), CR536-CR539.
dc.identifier.endpageCR539en_US
dc.identifier.issn1643-3750en_US
dc.identifier.issue11en_US
dc.identifier.pmid20980957en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpageCR536en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/25256
dc.identifier.volume16en_US
dc.identifier.wosWOS:000283991300008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTokaç, Mehmet
dc.institutionauthorErdem, Sami
dc.institutionauthorKaya, Coşkun
dc.institutionauthorÜnlü, Ali
dc.institutionauthorKarabağ, Turgut
dc.institutionauthorVatankulu, Mehmet Akif
dc.institutionauthorDemir, Kenan
dc.institutionauthorAyhan, Selim
dc.institutionauthorKaya, Ahmet
dc.language.isoenen_US
dc.publisherInt Scientific Information, Incen_US
dc.relation.ispartofMedical Science Monitoren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAsymmetric dimethylarginineen_US
dc.subjectObesityen_US
dc.titleSerum Asymmetric Dimethylarginine Levels in Normotensive Obese Individualsen_US
dc.typeArticleen_US

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