Alpha lipoic acid and vitamin E improve atorvastatin-induced mitochondrial dysfunctions in rats

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dc.contributor.authorEser Faki, Hatice
dc.contributor.authorTraş, Bünyamin
dc.contributor.authorÜney, Kamil
dc.date.accessioned2020-03-26T20:20:40Z
dc.date.available2020-03-26T20:20:40Z
dc.date.issued2020
dc.departmentSelçuk Üniversitesi, Veteriner Fakültesi, Klinik Öncesi Bilimler Bölümüen_US
dc.description.abstractTo determine the effects of alpha lipoic acid (ALA) and vitamin E (Vit E) on mitochondrial dysfunction caused by statins. A total of 38 Wistar Albino rats were used in this study. The control group received dimethyl sulfoxide. The atorvastatin (A) group received atorvastatin (10 mg/kg). The A + ALA group received atorvastatin (10 mg/kg) and ALA (100 mg/kg). The A + Vit E group was administered atorvastatin (10 mg/kg) and Vit E (100 mg/kg). The A + ALA + Vit E group was administered atorvastatin (10 mg/kg), ALA (100 mg/kg) and Vit E (100 mg/kg). All applications were administered simultaneously by gavage for 20 days. ATP level and complex I activity were measured from liver, muscle, heart, kidney and brain. Atorvastatin significantly decreased the ATP levels in heart and kidney, while a slight decrease was seen in liver, muscle and brain. Atorvastatin caused an insignificant decrease in the complex I activity in all tissues examined. ALA administration significantly improved the ATP levels in the liver, heart and kidney, while Vit E improved the ATP levels in all tissues except the muscle compared to Atorvastatin group. Single administration of both ALA and vit E ameliorated complex I activity in the muscle, heart, kidney and brain. The combination of ALA and Vit E significantly improved the ATP levels in the liver, heart, kidney and brain and also provided significant improvements the complex I activity in all tissues. The undesirable effects of Atorvastatin on mitochondrial functions in this study ameliorated by using ALA and/or Vit E alone and in combination.en_US
dc.identifier.citationEser Faki, H., Traş, B., Üney, K. (2020). Alpha Lipoic Acid And Vitamin E Improve Atorvastatin-Induced Mitochondrial Dysfunctions In Rats. Mitochondrion, 52, 83-88.
dc.identifier.doi10.1016/j.mito.2020.02.011en_US
dc.identifier.endpage88en_US
dc.identifier.issn1567-7249en_US
dc.identifier.pmid32119925en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage83en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.mito.2020.02.011
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38641
dc.identifier.volume52en_US
dc.identifier.wosWOS:000530229300009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorEser Faki, Hatice
dc.institutionauthorTraş, Bünyamin
dc.institutionauthorÜney, Kamil
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofMitochondrionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAlfa lipoic aciden_US
dc.subjectAtorvastatinen_US
dc.subjectATPen_US
dc.subjectComplex Ien_US
dc.subjectMitochondriaen_US
dc.subjectVitamin Een_US
dc.titleAlpha lipoic acid and vitamin E improve atorvastatin-induced mitochondrial dysfunctions in ratsen_US
dc.typeArticleen_US

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