Effects of glucose ıngestıon on serum fractalkıne levels ın healthy subjects and newly dıagnosed type 2 dıabetıc patıents

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dc.contributor.authorBaldane, Suleyman.
dc.contributor.authorKendir, Ismail Can.
dc.contributor.authorKirac, Cem Onur.
dc.contributor.authorIpekci, Suleyman.
dc.contributor.authorTekin, Gulsum.
dc.contributor.authorUnlu, Ali.
dc.contributor.authorKebapcilar, Levent.
dc.date.accessioned2020-03-26T19:53:40Z
dc.date.available2020-03-26T19:53:40Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü.en_US
dc.description.abstractBackground: Fractalkine (FKN) is an inflammatory cytokine that has been shown with increased serum levels in diabetic patients and is considered to contribute to the adipose tissue inflammation by supporting monocyte adhesion to adipocytes which has an important role in the pathogenesis of type 2 diabetes mellitus (T2DM). Our aim was to evaluate the effects of glucose ingestion on the serum fractalkine levels in healthy subjects with normal glucose tolerance (NGT) and newly diagnosed T2DM patients. Methods: A total of 67 patients were included in this study, and they were divided into NGT (n=34) and T2DM (n=33) groups according to their oral glucose tolerance test (OGTT) results. The serum FKN and C-reactive protein (CRP) levels were measured at 0 and 120 minutes during an OGTT following overnight fasting. Results: The 0-minute (basal) and 120-minute OGTT FKN levels were found to be significantly higher in the T2DM group when compared to the NGT group (p=0.012 and p=0.001, respectively). However, no significant differences were observed in terms of the changes in the basal and 120-minute OGTT FKN levels in the T2DM and NGT groups (p=0.433 and p=0.06, respectively). A significant positive correlation was observed between the 120-minute OGTT FKN and glucose levels in the study group consisting of all of the patients (r=0.331, p=0.006). Conclusions: In this study, basal and post-glycemic load FKN levels were found to be higher in newly diagnosed T2DM patients than those with NGT; however, there was no additional change in FKN levels by glycemic load.en_US
dc.description.sponsorshipSelcuk UniversitySelcuk University [BAP 16102008]en_US
dc.description.sponsorshipThis work was presented in part in abstract form at the 19th European Congress of Endocrinology, 2017, in Lisbon, Portugal. This study has been partially supported by Selcuk University under grant no: BAP 16102008.en_US
dc.identifier.citationBaldane, S., Kendir, I. C., Kirac, C. O., Ipekci, S., Tekin, G., Unlu, A., Kebapcilar, L. (2018). Effects of Glucose Ingestion on Serum Fractalkine Levels in Healthy Subjects and Newly Diagnosed Type 2 Diabetic Patients. Journal of Medical Biochemistry, 37(3), 373-378.
dc.identifier.doi10.1515/jomb-2017-0070en_US
dc.identifier.endpage378en_US
dc.identifier.issn1452-8258en_US
dc.identifier.issn1452-8266en_US
dc.identifier.issue3en_US
dc.identifier.pmid30598635en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage373en_US
dc.identifier.urihttps://dx.doi.org/10.1515/jomb-2017-0070
dc.identifier.urihttps://hdl.handle.net/20.500.12395/36564
dc.identifier.volume37en_US
dc.identifier.wosWOS:000439420700012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBaldane, Suleyman.
dc.institutionauthorKendir, Ismail Can.
dc.institutionauthorKirac, Cem Onur.
dc.institutionauthorIpekci, Suleyman.
dc.institutionauthorTekin, Gulsum.
dc.institutionauthorUnlu, Ali.
dc.institutionauthorKebapcilar, Levent.
dc.language.isoenen_US
dc.publisherSCIENDOen_US
dc.relation.ispartofJOURNAL OF MEDICAL BIOCHEMISTRYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectfractalkineen_US
dc.subjectinflammationen_US
dc.subjectoral glucose tolerance testen_US
dc.subjecttype 2 diabetes mellitusen_US
dc.titleEffects of glucose ıngestıon on serum fractalkıne levels ın healthy subjects and newly dıagnosed type 2 dıabetıc patıentsen_US
dc.typeArticleen_US

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