Selenium-induced changes on rat sciatic nerve fibers: Compound action potentials

Küçük Resim Yok

Tarih

2008

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

PROUS SCIENCE, SA-THOMSON REUTERS

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

The nervous system, through its important role as a communication network, governs reactions to stimuli, processes information and generates elaborate patterns of signals to control complex behaviors. Although selenium (Se) was shown to have some beneficial effects in pathological conditions, it is still a toxic element with a fairly small therapeutic window. In this study, the direct effects of Se ranging from 10(-8) to 10(-4) M were tested on rat sciatic nerve preparations. The toxicity started at 10-8 M and the degree of alterations was found to be dose-dependent. In between the measured parameters, total compound action potential area (Astart 3 70 +/- 0.16 ms x mV and A(-8) M = 3.04 +/- 0.14 ms x mV) and maximum depolarization points (MDstart = 6.70 +/- 0.22 mV and MD(-8) M = 6.04 +/- 0.18 mV) were the first to be affected from 10(-8) M. Latencies and conduction velocity distribution measurements have shown that nerve fibers having intermediate conduction velocities (20-35 m/s) are the first to be affected front this toxicity. Despite the fact that the new claims concluded the positive effects of the administrations, it is evident that the dose of supplementation must be fine-tuned to avoid possible side effects. Copyright 2008 Prous Science, S.A.U. or its licensors. All rights reserved.

Açıklama

Anahtar Kelimeler

compound action potential, conduction velocity group, sciatic nerve, selenium, toxicity

Kaynak

METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY

WoS Q Değeri

Q4

Scopus Q Değeri

N/A

Cilt

30

Sayı

4

Künye