Selenium-induced changes on rat sciatic nerve fibers: Compound action potentials

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dc.contributor.authorAyaz, Murat
dc.contributor.authorDalkilic, Nizamettin
dc.contributor.authorTuncer, Seckin
dc.contributor.authorBariskaner, Hulagu
dc.date.accessioned2020-03-26T17:27:43Z
dc.date.available2020-03-26T17:27:43Z
dc.date.issued2008
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe nervous system, through its important role as a communication network, governs reactions to stimuli, processes information and generates elaborate patterns of signals to control complex behaviors. Although selenium (Se) was shown to have some beneficial effects in pathological conditions, it is still a toxic element with a fairly small therapeutic window. In this study, the direct effects of Se ranging from 10(-8) to 10(-4) M were tested on rat sciatic nerve preparations. The toxicity started at 10-8 M and the degree of alterations was found to be dose-dependent. In between the measured parameters, total compound action potential area (Astart 3 70 +/- 0.16 ms x mV and A(-8) M = 3.04 +/- 0.14 ms x mV) and maximum depolarization points (MDstart = 6.70 +/- 0.22 mV and MD(-8) M = 6.04 +/- 0.18 mV) were the first to be affected from 10(-8) M. Latencies and conduction velocity distribution measurements have shown that nerve fibers having intermediate conduction velocities (20-35 m/s) are the first to be affected front this toxicity. Despite the fact that the new claims concluded the positive effects of the administrations, it is evident that the dose of supplementation must be fine-tuned to avoid possible side effects. Copyright 2008 Prous Science, S.A.U. or its licensors. All rights reserved.en_US
dc.description.sponsorshipScientific Committee Foundation of Selcuk University, Konya, Turkey.Selcuk University [06401013]en_US
dc.description.sponsorshipThe present research was supported through a grant from the Scientific Committee Foundation (Project Numbers: 06401013) of Selcuk University, Konya, Turkey.en_US
dc.identifier.doi10.1358/mf.2008.30.4.1166220en_US
dc.identifier.endpage275en_US
dc.identifier.issn0379-0355en_US
dc.identifier.issue4en_US
dc.identifier.pmid18773121en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage271en_US
dc.identifier.urihttps://dx.doi.org/10.1358/mf.2008.30.4.1166220
dc.identifier.urihttps://hdl.handle.net/20.500.12395/22630
dc.identifier.volume30en_US
dc.identifier.wosWOS:000259022400003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPROUS SCIENCE, SA-THOMSON REUTERSen_US
dc.relation.ispartofMETHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcompound action potentialen_US
dc.subjectconduction velocity groupen_US
dc.subjectsciatic nerveen_US
dc.subjectseleniumen_US
dc.subjecttoxicityen_US
dc.titleSelenium-induced changes on rat sciatic nerve fibers: Compound action potentialsen_US
dc.typeArticleen_US

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