Detection of Trisomy 12 and Centromeric Alterations in CLL by Interphase- and Metaphase-Fish
Yükleniyor...
Dosyalar
Tarih
1998
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
ELSEVIER SCIENCE INC
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
We have studied trisomy 12 in chronic lymphocytic leukemia (CLL) by fluorescence in situ hybridization (FISH) with an alpha-satellite centromeric probe for chromosome 12 on both dividing and non-dividing cells. Trisomy for chromosome 12 tvas demonstrated in four of these patients (15.3%) using FISH on interphase cells. The percentage of trisomic cells ranged from 10% to 65% of nuclei. The hybridization signals in the trisomic and disomic nuclei were of a broadly similar size and nature. Interestingly, three of the remaining CLL patients, who exhibited disomy for chromosome 12, showed a marked difference in size of the hybridization signals in interphase nuclei. This was also demonstrated in metaphase spreads. In addition, metaphase FISH studies revealed a supernumerary marker chromosome in three out of 26 patients with CLL.
Açıklama
Anahtar Kelimeler
Kaynak
Cancer Genetics and Cytogenetics
WoS Q Değeri
Q2
Scopus Q Değeri
N/A
Cilt
100
Sayı
2
Künye
Acar, H., Connor, M. J., (1998). Detection of Trisomy 12 and Centromeric Alterations in CLL by Interphase- and Metaphase-Fish. Cancer Genetics and Cytogenetics, 100(2), 148-151. doi: 10.1016/S0165-4608(97)00024-1
