Detection of Trisomy 12 and Centromeric Alterations in CLL by Interphase- and Metaphase-Fish

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dc.contributor.authorAcar, Hasan
dc.contributor.authorConnor, Micheal J.
dc.date.accessioned2020-03-26T16:26:07Z
dc.date.available2020-03-26T16:26:07Z
dc.date.issued1998
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractWe have studied trisomy 12 in chronic lymphocytic leukemia (CLL) by fluorescence in situ hybridization (FISH) with an alpha-satellite centromeric probe for chromosome 12 on both dividing and non-dividing cells. Trisomy for chromosome 12 tvas demonstrated in four of these patients (15.3%) using FISH on interphase cells. The percentage of trisomic cells ranged from 10% to 65% of nuclei. The hybridization signals in the trisomic and disomic nuclei were of a broadly similar size and nature. Interestingly, three of the remaining CLL patients, who exhibited disomy for chromosome 12, showed a marked difference in size of the hybridization signals in interphase nuclei. This was also demonstrated in metaphase spreads. In addition, metaphase FISH studies revealed a supernumerary marker chromosome in three out of 26 patients with CLL.en_US
dc.identifier.citationAcar, H., Connor, M. J., (1998). Detection of Trisomy 12 and Centromeric Alterations in CLL by Interphase- and Metaphase-Fish. Cancer Genetics and Cytogenetics, 100(2), 148-151. doi: 10.1016/S0165-4608(97)00024-1
dc.identifier.doi10.1016/S0165-4608(97)00024-1en_US
dc.identifier.endpage151en_US
dc.identifier.issn0165-4608en_US
dc.identifier.issue2en_US
dc.identifier.pmid9428359en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage148en_US
dc.identifier.urihttps://dx.doi.org/10.1016/S0165-4608(97)00024-1
dc.identifier.urihttps://hdl.handle.net/20.500.12395/16755
dc.identifier.volume100en_US
dc.identifier.wosWOS:000071133300009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAcar, Hasan
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE INCen_US
dc.relation.ispartofCancer Genetics and Cytogeneticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleDetection of Trisomy 12 and Centromeric Alterations in CLL by Interphase- and Metaphase-Fishen_US
dc.typeArticleen_US

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