Comparative Pharmacokinetics of Enrofloxacin and Tissue Concentrations of Parent Drug and Ciprofloxacin After Intramuscular Administrations of Free and Liposome-encapsulated Enrofloxacin in Rabbits

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dc.contributor.authorElmas, Muammer
dc.contributor.authorYazar, Enver
dc.contributor.authorBaş, A.L.
dc.contributor.authorTraş, Bünyamin
dc.contributor.authorBayezit, M.
dc.contributor.authorYapar, K.
dc.date.accessioned2020-03-26T16:38:47Z
dc.date.available2020-03-26T16:38:47Z
dc.date.issued2002
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPharmacokinetic properties and tissue concentrations of enrofloxacin and ciprofloxacin were compared after intramuscular (i.m.) administrations of free and liposome-encapsulated enrofloxacin at the dose of 5 mg/kg body weight (bw). Twelve healthy adult New Zealand white rabbits were used in the experiment. Blood samples were obtained at 10, 20, 40, 60 and 90 min and 2, 4, 6, 8 and 12 h and tissue samples were collected 24 h after injection. Concentrations of drugs in serum were determined by high-performance liquid chromatography. Pharmacokinetics were best described by a two-compartment open model. Results indicated that absorption rate was slow, peak concentration was higher (P<0.05), and the time to peak concentration (t(max) congruent to 1.5 h) was significantly longer (P<0.05) for liposome-encapsulated enrofloxacin (LEE) when compared with free enrofloxacin. Values of elimination half-life (t(1/2beta)=12.9 h) and mean residence time (MRT=17.6 h) of liposome-encapsulated enrofloxacin were longer (P<0.05) and total clearance (Cl = 0.43 l/h/kg) was lower than those of free form. Moreover, the distribution volume at steady-state (V-d(ss)=14.4 l/kg) of enrofloxacin administered encapsulated into liposomes was significantly higher (P<0.05) than that of free enrofloxacin (FE). The tissue levels of enrofloxacin and ciprofloxacin after LEE injection were not different (P>0.05) from FE. In conclusion, the result of present study suggest that LEE may be a beneficial and valuable formulation in the treatment of infectious diseases caused by sensitive pathogens in animals, providing sustained drug release from injection side and prolonged therapeutic serum concentrations after i.m. administration.en_US
dc.identifier.citationElmas, M., Yazar, E., Baş, A.L., Traş, B., Bayezit, M., Yapar, K., (2002). Comparative Pharmacokinetics of Enrofloxacin and Tissue Concentrations of Parent Drug and Ciprofloxacin After Intramuscular Administrations of Free and Liposome-encapsulated Enrofloxacin in Rabbits. Journal of Veterinary Medicine Series B-infectious Diseases and Veterinary Public Health, 49(10), 507-512 Doi: 10.1046/j.1439-0450.2002.00603.x
dc.identifier.doi10.1046/j.1439-0450.2002.00603.xen_US
dc.identifier.endpage512en_US
dc.identifier.issn0931-1793en_US
dc.identifier.issue10en_US
dc.identifier.pmid12485362en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage507en_US
dc.identifier.urihttps://dx.doi.org/10.1046/j.1439-0450.2002.00603.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17908
dc.identifier.volume49en_US
dc.identifier.wosWOS:000179802900009en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorElmas, Muammer
dc.institutionauthorYazar, Enver
dc.institutionauthorBaş, A.L.
dc.institutionauthorTraş, Bünyamin
dc.language.isoenen_US
dc.publisherBLACKWELL VERLAG GMBHen_US
dc.relation.ispartofJournal of Veterinary Medicine Series B-infectious Diseases and Veterinary Public Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleComparative Pharmacokinetics of Enrofloxacin and Tissue Concentrations of Parent Drug and Ciprofloxacin After Intramuscular Administrations of Free and Liposome-encapsulated Enrofloxacin in Rabbitsen_US
dc.typeArticleen_US

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