Effects of melatonin on spermatogenesis and testicular ischemia-reperfusion injury after unilateral testicular torsion-detorsion
Küçük Resim Yok
Tarih
2008
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
W B SAUNDERS CO-ELSEVIER INC
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Purpose: This study aimed to determine the effect of melatonin in preventing ischemia-reperfusion (I-R) injury-induced tissue damage and on spermatogenesis after experimental testicular torsion (TT). Methods: Forty peripubertal rats were divided into 4 groups each containing 10 rats: control (C), sham (S), torsion plus detorsion (TD), and torsion plus melatonin (M). The left testes were rotated 720 degrees for 6 hours and detorsed for 6 hours thereafter. Serum inhibin B (113) levels were measured in blood samples taken from all groups. Left orchiectomies were performed to determine the tissue levels of Johnsen's scores (JS) and malondialdehyde (MDA). Results: Serum IB levels in the S and TD groups were significantly lower compared with that in the C group, whereas they were higher in the M group compared with the TD group. The MDA levels were significantly lower in the C, S, and, M groups compared with the TD group. Johnsen's scores were significantly higher in the C, S, and M groups compared with the TD group. Conclusions: Our results suggested that melatonin is a potent antioxidant agent in preventing testicular I-R injury, as shown by increased IB levels and JS. (C) 2008 Elsevier Inc. All rights reserved.
Açıklama
Anahtar Kelimeler
Testicular torsion, Inhibin B, Malondialdehyde, Johnsen's score, Melatonin
Kaynak
JOURNAL OF PEDIATRIC SURGERY
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
43
Sayı
10
