Effects of melatonin on spermatogenesis and testicular ischemia-reperfusion injury after unilateral testicular torsion-detorsion

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dc.contributor.authorYurtçu, Müslim
dc.contributor.authorAbasıyanık, Adnan
dc.contributor.authorAvınduk, Mustafa Cihat
dc.contributor.authorMuhtaroğlu, Sabahattin
dc.date.accessioned2020-03-26T17:26:45Z
dc.date.available2020-03-26T17:26:45Z
dc.date.issued2008
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPurpose: This study aimed to determine the effect of melatonin in preventing ischemia-reperfusion (I-R) injury-induced tissue damage and on spermatogenesis after experimental testicular torsion (TT). Methods: Forty peripubertal rats were divided into 4 groups each containing 10 rats: control (C), sham (S), torsion plus detorsion (TD), and torsion plus melatonin (M). The left testes were rotated 720 degrees for 6 hours and detorsed for 6 hours thereafter. Serum inhibin B (113) levels were measured in blood samples taken from all groups. Left orchiectomies were performed to determine the tissue levels of Johnsen's scores (JS) and malondialdehyde (MDA). Results: Serum IB levels in the S and TD groups were significantly lower compared with that in the C group, whereas they were higher in the M group compared with the TD group. The MDA levels were significantly lower in the C, S, and, M groups compared with the TD group. Johnsen's scores were significantly higher in the C, S, and M groups compared with the TD group. Conclusions: Our results suggested that melatonin is a potent antioxidant agent in preventing testicular I-R injury, as shown by increased IB levels and JS. (C) 2008 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.jpedsurg.2008.01.065en_US
dc.identifier.endpage1878en_US
dc.identifier.issn0022-3468en_US
dc.identifier.issn1531-5037en_US
dc.identifier.issue10en_US
dc.identifier.pmid18926224en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1873en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.jpedsurg.2008.01.065
dc.identifier.urihttps://hdl.handle.net/20.500.12395/22360
dc.identifier.volume43en_US
dc.identifier.wosWOS:000260359300020en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B SAUNDERS CO-ELSEVIER INCen_US
dc.relation.ispartofJOURNAL OF PEDIATRIC SURGERYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectTesticular torsionen_US
dc.subjectInhibin Ben_US
dc.subjectMalondialdehydeen_US
dc.subjectJohnsen's scoreen_US
dc.subjectMelatoninen_US
dc.titleEffects of melatonin on spermatogenesis and testicular ischemia-reperfusion injury after unilateral testicular torsion-detorsionen_US
dc.typeArticleen_US

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