Determination of Intracellular Concentrations of Free and Two Types of Liposome-Encapsulated Enrofloxacin in Anatolian Shepherd Dog Monocytes

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dc.contributor.authorBaş, Ahmet Levent
dc.contributor.authorŞimşek, Atilla
dc.contributor.authorÇorlu, M.
dc.contributor.authorYazar, Enver
dc.contributor.authorElmas, Muammer
dc.contributor.authorDeğim, Zeliha Gül
dc.date.accessioned2020-03-26T16:38:52Z
dc.date.available2020-03-26T16:38:52Z
dc.date.issued2002
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn this study, it was evaluated the accumulation of free and two types of liposome-encapsulated enrofloxacin (LEE) at the doses of 0.25, 0.5 and 1 mu g/ml, which were clinically relevant concentrations into monocytes of healthy Anatolian shepherd dogs. Enrofloxacin was encapsulated with two different types of liposome in multilamellar large vesicles (MLV). Type A MLV composed of 15 mg egg phosphatidylcholine and 35 mg cholesterol, Type B MLV composed of phosphatidylcholine (PC), cholesterol and enrofloxacin, in a molar ratio of 1 : 1 : 1. The mean sizes of Type A and Type B liposome were found to be 7.65 and 4.27 mu m, respectively. However, the mean encapsulation rate determined of Type A (13 +/- 2%) was found lower than Type B liposome (44 +/- 3%). The amounts of intracellular enrofloxacin concentrations were determined by high performance liquid chromatography. Type B LEE accumulated significantly higher level into monocytes when compared to free drug or Type A liposome. This study showed that Type B LEE markedly concentrated within monocytes and may improve the antibacterial efficacy of the antibiotic.en_US
dc.identifier.citationBaş, A. L., Şimşek, A., Çorlu, M., Yazar, E., Elmas, M., Değim, Z. G., (2002). Determination of Intracellular Concentrations of Free and Two Types of Liposome-encapsulated Enrofloxacin in Anatolian Shepherd Dog Monocytes. Journal of Veterinary Medicine Series B-infectious Diseases and Veterinary Public Health, (49), 289-293. Doi: 10.1046/j.1439-0450.2002.00568.x
dc.identifier.doi10.1046/j.1439-0450.2002.00568.xen_US
dc.identifier.endpage293en_US
dc.identifier.issn0931-1793en_US
dc.identifier.pmid12241030en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage289en_US
dc.identifier.urihttps://dx.doi.org/10.1046/j.1439-0450.2002.00568.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17921
dc.identifier.volume49en_US
dc.identifier.wosWOS:000177704800006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBaş, Ahmet Levent
dc.institutionauthorŞimşek, Atilla
dc.institutionauthorÇorlu, M.
dc.institutionauthorYazar, Enver
dc.institutionauthorElmas, Muammer
dc.language.isoenen_US
dc.publisherBlackwell Verlag Gmbhen_US
dc.relation.ispartofJournal of Veterinary Medicine Series B-infectious Diseases and Veterinary Public Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleDetermination of Intracellular Concentrations of Free and Two Types of Liposome-Encapsulated Enrofloxacin in Anatolian Shepherd Dog Monocytesen_US
dc.typeArticleen_US

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