Proliferation effects of phenylboronic acid and boric acid on canine peripheral blood mononuclear cells
Yükleniyor...
Dosyalar
Tarih
2019
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
SCIENTIFIC TECHNICAL RESEARCH COUNCIL TURKEY-TUBITAK
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The effects of phenylboronic acid (PBA) and boric acid (BA) on the proliferation of canine peripheral blood mononuclear cells (PBMCs) were investigated. Treatment of PBMCs from mixed breed dogs with PBA or BA (0.05 mu g/mL) alone elicited blastogenic responses of 0.478 +/- 0.438 and 0.499 +/- 0.366, respectively. We observed an additive effect on proliferation when purebred Kangal PBMCs were cultured in a combination of BA (0.001 mu g/mL) and the mitogenic lectin concanavalin A (1 mu g/mL). However, the effects were not statistically significant. We detected varied IL-2 and IL-4 secretion in response to stimulation with boron-containing compounds. Our findings suggest that PBA induces canine PBMC proliferation, albeit less potently than lectins. However, boronic acid compounds may still prove beneficial as adjuvants to elicit cell proliferation and boost canine immune responses.
Açıklama
Anahtar Kelimeler
Boric acid, canine, mitogen, phenylboronic acid, proliferation
Kaynak
TURKISH JOURNAL OF VETERINARY & ANIMAL SCIENCES
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
43
Sayı
2
Künye
Uçan, U. S., Sayın, Z. (2019). Proliferation Effects of Phenylboronic Acid and Boric Acid on Canine Peripheral Blood Mononuclear Cells. Turkish Journal of Veterinary and Animal Sciences, 43(2), 229-234.
