Proliferation effects of phenylboronic acid and boric acid on canine peripheral blood mononuclear cells

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dc.authorid0000-0002-2677-179X
dc.authorid0000-0001-6096-4440
dc.contributor.authorUçan, Uçkun Sait.
dc.contributor.authorSayın, Zafer.
dc.date.accessioned2020-03-26T20:19:11Z
dc.date.available2020-03-26T20:19:11Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Veteriner Fakültesi, Klinik Öncesi Bilimler Bölümüen_US
dc.description.abstractThe effects of phenylboronic acid (PBA) and boric acid (BA) on the proliferation of canine peripheral blood mononuclear cells (PBMCs) were investigated. Treatment of PBMCs from mixed breed dogs with PBA or BA (0.05 mu g/mL) alone elicited blastogenic responses of 0.478 +/- 0.438 and 0.499 +/- 0.366, respectively. We observed an additive effect on proliferation when purebred Kangal PBMCs were cultured in a combination of BA (0.001 mu g/mL) and the mitogenic lectin concanavalin A (1 mu g/mL). However, the effects were not statistically significant. We detected varied IL-2 and IL-4 secretion in response to stimulation with boron-containing compounds. Our findings suggest that PBA induces canine PBMC proliferation, albeit less potently than lectins. However, boronic acid compounds may still prove beneficial as adjuvants to elicit cell proliferation and boost canine immune responses.en_US
dc.description.sponsorshipScientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [1150940]en_US
dc.description.sponsorshipThis work was supported by the Scientific and Technological Research Council of Turkey (Project Number: 1150940).en_US
dc.identifier.citationUçan, U. S., Sayın, Z. (2019). Proliferation Effects of Phenylboronic Acid and Boric Acid on Canine Peripheral Blood Mononuclear Cells. Turkish Journal of Veterinary and Animal Sciences, 43(2), 229-234.
dc.identifier.doi10.3906/vet-1810-54en_US
dc.identifier.endpage234en_US
dc.identifier.issn1300-0128en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage229en_US
dc.identifier.urihttps://dx.doi.org/10.3906/vet-1810-54
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38131
dc.identifier.volume43en_US
dc.identifier.wosWOS:000463338800007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorUçan, Uçkun Sait.
dc.institutionauthorSayın, Zafer.
dc.language.isoenen_US
dc.publisherSCIENTIFIC TECHNICAL RESEARCH COUNCIL TURKEY-TUBITAKen_US
dc.relation.ispartofTURKISH JOURNAL OF VETERINARY & ANIMAL SCIENCESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectBoric aciden_US
dc.subjectcanineen_US
dc.subjectmitogenen_US
dc.subjectphenylboronic aciden_US
dc.subjectproliferationen_US
dc.titleProliferation effects of phenylboronic acid and boric acid on canine peripheral blood mononuclear cellsen_US
dc.typeArticleen_US

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