Effects of Tylosin on Serum Cytokine Levels in Healthy and Lipopolysaccharide-Treated Mice

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dc.contributor.authorEr, Ayşe
dc.contributor.authorYazar, Enver
dc.contributor.authorÜney, Kamil
dc.contributor.authorElmas, Muammer
dc.contributor.authorAltan, Feray
dc.contributor.authorÇetin, Gül
dc.date.accessioned2020-03-26T17:48:22Z
dc.date.available2020-03-26T17:48:22Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe effects of different doses of tylosin on serum cytokine concentrations were investigated in healthy and lipopolysaccharide-treated mice. The mice were divided into seven groups. Lipopolysaccharide (LPS) was injected into the positive control group. The other six groups received three different tylosin doses concurrently without or with LPS: 10 mg/kg, 100 mg/kg, 500 mg/kg, 10 mg/kg + LPS, 100 mg/kg + LPS and 500 mg/kg + LPS. After treatment, serum samples were collected at 0, 1, 2, 3, 6, 12 and 24 hours. Serum tumour necrosis factor alpha (TNF alpha), interleukin 1 beta (IL1 beta) and IL10 levels were determined by enzyme-linked immunosorbent assay (ELISA). Tylosin doses of 10 and 100 mg/kg induced no cytokine production in the healthy mice. Tylosin at 500 mg/kg had no effect on TNF alpha or IL1 beta production, but it induced IL10 production in healthy mice. All doses of tylosin reduced the elevated TNF alpha and IL1 beta in LPS-treated mice but increased their IL10 levels. In conclusion, these data suggest that tylosin has an immunomodulatory effect at the dose recommended for use against infection.en_US
dc.description.sponsorshipSUBAKSelcuk University [08401070]en_US
dc.description.sponsorshipThis study was supported by SUBAK (08401070).en_US
dc.identifier.citationEr, A., Yazar, E., Üney, K., Elmas, M., Altan, F., Çetin, G., (2010). Effects of Tylosin on Serum Cytokine Levels in Healthy and Lipopolysaccharide-Treated Mice. Acta Veterinaria Hungarica, 58(1), 75-81. Doi: 10.1556/AVet.58.2010.1.8
dc.identifier.doi10.1556/AVet.58.2010.1.8en_US
dc.identifier.endpage81en_US
dc.identifier.issn0236-6290en_US
dc.identifier.issn1588-2705en_US
dc.identifier.issue1en_US
dc.identifier.pmid20159741en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage75en_US
dc.identifier.urihttps://dx.doi.org/10.1556/AVet.58.2010.1.8
dc.identifier.urihttps://hdl.handle.net/20.500.12395/24873
dc.identifier.volume58en_US
dc.identifier.wosWOS:000274582400008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorEr, Ayşe
dc.institutionauthorYazar, Enver
dc.institutionauthorÜney, Kamil
dc.institutionauthorElmas, Muammer
dc.institutionauthorÇetin, Gül
dc.language.isoenen_US
dc.publisherAkademiai Kiado Zrten_US
dc.relation.ispartofActa Veterinaria Hungaricaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectTylosinen_US
dc.subjectLpsen_US
dc.subjectTNF alphaen_US
dc.subjectIL1 betaen_US
dc.subjectIL10en_US
dc.titleEffects of Tylosin on Serum Cytokine Levels in Healthy and Lipopolysaccharide-Treated Miceen_US
dc.typeArticleen_US

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