The Response of Isolated Anti-HBc Positive Subjects to Recombinant Hepatitis B Vaccine
Yükleniyor...
Tarih
2001
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
W B SAUNDERS CO LTD
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: The aim of this study was to evaluate the response to hepatitis B vaccination in isolated anti-HBc positive subjects. Patients and Methods: Forty-eight subjects with persistent isolated core antibody were included in the study. Fifty healthy people who were negative for HBsAg, anti-HBs and anti-HBc were included in the study as a control group. They all were vaccinated with recombinant hepatitis B vaccine at 0, 1 and 2 months. Results: Thirty days after each dose of vaccination, serum levels over 10 IU/l of anti-HBs are found in 50% of the subjects with isolated anti-HBc after first; in 68.7 lo after second and in 89.6% after third vaccination. There were no statistical differences between the two groups (P > 0.05). Twenty subjects in isolated anti-HBc group (41.6%) but none of the subjects from the control group responded with a titer of > 50 IU/l after 30 days, which suggested an anamnestic response due to prior infection and immunity. Furthermore, 23 subjects in isolated anti-HBc group (47.9%) finally responded after three doses of vaccination (anti-HBs titer > 10 IU/l) thus excluding chronic infection and suggesting initial false positive results. Conclusions: In isolated anti-HBc subjects false positive results (primary response) or prior infection by HBV (anamnestic response) can be detected by anti-HBs response after HBV vaccination.
Açıklama
Anahtar Kelimeler
Kaynak
Journal of Infection
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
43
Sayı
3
Künye
Ural, O., Fındık, D., (2001). The Response of Isolated Anti-HBc Positive Subjects to Recombinant Hepatitis B Vaccine. Journal of Infection, 43(3), 187-190. Doi:10.1053/jinf.2001.0878
