The Response of Isolated Anti-HBc Positive Subjects to Recombinant Hepatitis B Vaccine

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dc.contributor.authorUral, O.
dc.contributor.authorFındık, D.
dc.date.accessioned2020-03-26T16:37:30Z
dc.date.available2020-03-26T16:37:30Z
dc.date.issued2001
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to evaluate the response to hepatitis B vaccination in isolated anti-HBc positive subjects. Patients and Methods: Forty-eight subjects with persistent isolated core antibody were included in the study. Fifty healthy people who were negative for HBsAg, anti-HBs and anti-HBc were included in the study as a control group. They all were vaccinated with recombinant hepatitis B vaccine at 0, 1 and 2 months. Results: Thirty days after each dose of vaccination, serum levels over 10 IU/l of anti-HBs are found in 50% of the subjects with isolated anti-HBc after first; in 68.7 lo after second and in 89.6% after third vaccination. There were no statistical differences between the two groups (P > 0.05). Twenty subjects in isolated anti-HBc group (41.6%) but none of the subjects from the control group responded with a titer of > 50 IU/l after 30 days, which suggested an anamnestic response due to prior infection and immunity. Furthermore, 23 subjects in isolated anti-HBc group (47.9%) finally responded after three doses of vaccination (anti-HBs titer > 10 IU/l) thus excluding chronic infection and suggesting initial false positive results. Conclusions: In isolated anti-HBc subjects false positive results (primary response) or prior infection by HBV (anamnestic response) can be detected by anti-HBs response after HBV vaccination.en_US
dc.identifier.citationUral, O., Fındık, D., (2001). The Response of Isolated Anti-HBc Positive Subjects to Recombinant Hepatitis B Vaccine. Journal of Infection, 43(3), 187-190. Doi:10.1053/jinf.2001.0878
dc.identifier.doi10.1053/jinf.2001.0878en_US
dc.identifier.endpage190en_US
dc.identifier.issn0163-4453en_US
dc.identifier.issue3en_US
dc.identifier.pmid11798257en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage187en_US
dc.identifier.urihttps://dx.doi.org/10.1053/jinf.2001.0878
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17634
dc.identifier.volume43en_US
dc.identifier.wosWOS:000172195500006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorUral, O.
dc.institutionauthorFındık, D.
dc.language.isoenen_US
dc.publisherW B SAUNDERS CO LTDen_US
dc.relation.ispartofJournal of Infectionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleThe Response of Isolated Anti-HBc Positive Subjects to Recombinant Hepatitis B Vaccineen_US
dc.typeArticleen_US

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