Effect of ethyl acetate extract of usnea longissima on esophagogastric adenocarcinoma in rats
Yükleniyor...
Dosyalar
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
ACTA CIRURGICA BRASILEIRA
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Purpose: To investigate the effects of the EtOAc extract of U. longissima which is uninvestigated previously on esophagogastric cancer induced in rats with N-methyl-N-nitro-N-nitrosoguanidin (MNNG). Methods: The anticancer activity of EtOAc extract of U. longissima was examined in the esophagogastric adenocarcinoma models induced in rats with MNNG. EtOAc extract of U. longissima, 50 and 100 mg/kg oral doses were administered once daily for six months. MNNG induced differentiated and undifferentiated type adenocarcinomas in the esophageal and gastric tissues of rats. Results: EtOAc extract of U. longissima obtained from U. longissima prevented gastric and esophageal cancerogenesis induced in rats with MNNG. EtOAc extract of U. longissima did not have a lethal effect at doses of 500, 1000 and 2000 mg/kg. The prominent anticarcinogenic activity of EtOAc extract of U. longissima 50 and 100 mg/kg suggests that it is not toxic and it is selective to the cancer tissue. Conclusion: This information may shed light on clinical implementation of EtOAc extract of U. longissima in future.
Açıklama
Anahtar Kelimeler
Adenocarcinoma, Acetates, Usnea, Rats
Kaynak
ACTA CIRURGICA BRASILEIRA
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
34
Sayı
3
Künye
Mammadov, R., Suleyman, B., Altuner, D., Demirci, E., Cetin, N., Yilmaz, A., Baykal, H., Alpcan, H., Turumtay, E. A., Suleyman, H. (2019). Effect of Ethyl Acetate Extract of Usnea Longissima on Esophagogastric Adenocarcinoma in Rats. Acta Cirurgica Brasileira, 34(3), e201900305.
