Effect of ethyl acetate extract of usnea longissima on esophagogastric adenocarcinoma in rats

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dc.authorid0000-0002-9239-4099
dc.contributor.authorMammadov, Renad
dc.contributor.authorSüleyman, Bahadır
dc.contributor.authorAltuner, Durdu
dc.contributor.authorDemirci, Elif
dc.contributor.authorÇetin, Nihal
dc.contributor.authorYılmaz, Adnan
dc.contributor.authorBaykal, Hüseyin
dc.contributor.authorAlpcan, Hilal
dc.contributor.authorTurumtay, Emine Akyüz
dc.contributor.authorSüleyman, Halis
dc.date.accessioned2020-03-26T20:13:36Z
dc.date.available2020-03-26T20:13:36Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractPurpose: To investigate the effects of the EtOAc extract of U. longissima which is uninvestigated previously on esophagogastric cancer induced in rats with N-methyl-N-nitro-N-nitrosoguanidin (MNNG). Methods: The anticancer activity of EtOAc extract of U. longissima was examined in the esophagogastric adenocarcinoma models induced in rats with MNNG. EtOAc extract of U. longissima, 50 and 100 mg/kg oral doses were administered once daily for six months. MNNG induced differentiated and undifferentiated type adenocarcinomas in the esophageal and gastric tissues of rats. Results: EtOAc extract of U. longissima obtained from U. longissima prevented gastric and esophageal cancerogenesis induced in rats with MNNG. EtOAc extract of U. longissima did not have a lethal effect at doses of 500, 1000 and 2000 mg/kg. The prominent anticarcinogenic activity of EtOAc extract of U. longissima 50 and 100 mg/kg suggests that it is not toxic and it is selective to the cancer tissue. Conclusion: This information may shed light on clinical implementation of EtOAc extract of U. longissima in future.en_US
dc.identifier.citationMammadov, R., Suleyman, B., Altuner, D., Demirci, E., Cetin, N., Yilmaz, A., Baykal, H., Alpcan, H., Turumtay, E. A., Suleyman, H. (2019). Effect of Ethyl Acetate Extract of Usnea Longissima on Esophagogastric Adenocarcinoma in Rats. Acta Cirurgica Brasileira, 34(3), e201900305.
dc.identifier.doi10.1590/s0102-865020190030000005en_US
dc.identifier.issn0102-8650en_US
dc.identifier.issn1678-2674en_US
dc.identifier.issue3en_US
dc.identifier.pmid30892391en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://dx.doi.org/10.1590/s0102-865020190030000005
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37727
dc.identifier.volume34en_US
dc.identifier.wosWOS:000461476800004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorCetin, Nihal.
dc.language.isoenen_US
dc.publisherACTA CIRURGICA BRASILEIRAen_US
dc.relation.ispartofACTA CIRURGICA BRASILEIRAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAdenocarcinomaen_US
dc.subjectAcetatesen_US
dc.subjectUsneaen_US
dc.subjectRatsen_US
dc.titleEffect of ethyl acetate extract of usnea longissima on esophagogastric adenocarcinoma in ratsen_US
dc.typeArticleen_US

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