Philadelphia Chromosome in Chronic Myelogenous Leukemia: Confirmation of Cytogenetic Diagnosis in Ph Positive and Negative Cases by Fluorescence in Situ Hybridization
Yükleniyor...
Dosyalar
Tarih
1997
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
ELSEVIER SCIENCE INC
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
In this study, patients with Philadelphia (Ph) negative and positive chronic myelogenous leukemia (CML) were analyzed by unicolor- and dual color- (DC-) fluorescence in situ hybridization (FISH) using abl and bcr cosmid probes. Unicolor- and DC-FlSH analysis revealed a BCR-ABL fusion in a Ph-negative patient. DC-FISH to interphase nuclei revealed the BCR-ABL fusion, even though no metaphases were available for metaphase-FISH and conventional cytogenetic analysis. In the remaining cases, the findings of FISH were in agreement with the cytogenetic results.
Açıklama
Anahtar Kelimeler
Kaynak
Cancer Genetics and Cytogenetics
WoS Q Değeri
Q2
Scopus Q Değeri
N/A
Cilt
94
Sayı
2
Künye
Acar, H., Stewart, J., Connor, M. J., (1997). Philadelphia Chromosome in Chronic Myelogenous Leukemia: Confirmation of Cytogenetic Diagnosis in Ph Positive and Negative Cases by Fluorescence in Situ Hybridization. Cancer Genetics and Cytogenetics, 94(2), 75-78. doi:10.1016/S0165-4608(96)00167-7
