Preventing oxygen free radical damage by proanthocyanidin in obstructive jaundice

Basit Öğe Kaydı
dc.contributor.authorSavdan, Mervan
dc.contributor.authorCakir, Murat
dc.contributor.authorVatansev, Husamettin
dc.contributor.authorKucukkartallar, Tevfik
dc.contributor.authorTekin, Ahmet
dc.contributor.authorTavli, Sakir
dc.date.accessioned2020-03-26T19:42:23Z
dc.date.available2020-03-26T19:42:23Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: Tissue damage and endotoxemia in obstructive jaundice are attributed to the increase in oxygen free-radicals. We aimed at evaluating the possible protective effect of grape seed proanthocyanidin extract (GSPE), which is a potent exogenous free-radical scavenger and antioxidant. Material and Methods: The study was performed at the Necmettin Erbakan University Meram School of Medicine Research and Application Center for Experimental Medicine Laboratory with ethical approval. 30 Wistar-Albino rats were used and were divided into 3 groups. The common bile duct was identified and only dissected in the first group (sham). Following dissection of the common bile duct it was ligated with 4/0 silk just above the pancreas in the second group (control). After ligation of the common bile duct, 100mg/kg/day GSPE was administered via orogastric lavage for 10 days in the third group. Results: Biochemical values revealed a statistically significant difference between Group I and the others. There was no difference between Group II and III regarding biochemical values. There was a statistically significant difference, however, between Group II and III with regards to nitric oxide levels. There was a statistically significant difference between Group I and the other groups concerning hepatic and pulmonary tissue damage on histopathologic evaluation. There was no difference among the groups with regards to renal tubular damage. Conclusion: Proanthocyanidin is an effective natural antioxidant in decreasing the level of tissue damage caused by oxygen free-radicals.en_US
dc.identifier.doi10.5152/turkjsurg.2017.3337en_US
dc.identifier.endpage68en_US
dc.identifier.issn2564-6850en_US
dc.identifier.issn2564-7032en_US
dc.identifier.issue2en_US
dc.identifier.pmid28740952en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage62en_US
dc.identifier.urihttps://dx.doi.org/10.5152/turkjsurg.2017.3337
dc.identifier.urihttps://hdl.handle.net/20.500.12395/35402
dc.identifier.volume33en_US
dc.identifier.wosWOS:000403585500005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAVESen_US
dc.relation.ispartofTURKISH JOURNAL OF SURGERYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAntioxidanten_US
dc.subjectjaundiceen_US
dc.subjectproanthocyanidinen_US
dc.titlePreventing oxygen free radical damage by proanthocyanidin in obstructive jaundiceen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu