Effects of Bupivacaine and Ropivacaine on Hemodynamic Parameters in Rabbits
Yükleniyor...
Dosyalar
Tarih
2001
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
PROUS SCIENCE, SA
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
In the present study the toxic effects of ropivacaine and bupiavacaine on the cardiovascular and respiratory systems of rabbits were studied. Both drugs were administered intravenously at doses of 0.5, 1, 2.5, 5 and 10 mu mol/kg. The effects of the two drugs on blood pressure, ECG and respiration rate were evaluated by considering the changes occurring 30 sec after intravenous bolus injection. High doses (5 and 10 mu mol/kg) of bupivacaine and ropivacaine significantly reduced the heart rate and systolic pressure (p < 0.05). Five and 10 mu mol/kg of bupivacaine significantly reduced diastolic pressure (p < 0.05), but only the 10 mu mol/kg dose of ropivacaine had the same effect. Low doses of bupivacaine and high doses of ropivacaine significantly increased the PR interval, QRS duration and QT interval (p < 0.05). The 5 mu mol/kg dose of bupivacaine caused ventricular tachycardia in 3 of 6 rabbits, whereas ropivacaine caused tachycardia in 1 of 5 rabbits. Neither drug had a significant effect on respiration rate or blood gas values (p > 0.05). The results indicate that ropivacaine is less cardiodepressive and arrhythmogenic than bupivacaine.
Açıklama
Anahtar Kelimeler
Bupivacaine, Rabbit, Ropivacaine, Toxic Effect
Kaynak
Methods and Findings in Experimental and Clinical Pharmacology
WoS Q Değeri
Q4
Scopus Q Değeri
N/A
Cilt
23
Sayı
2
Künye
Barışkaner, H., Tuncer, S., Ulusoy, H., Doğan, N., (2001). Effects of Bupivacaine and Ropivacaine on Hemodynamic Parameters in Rabbits. Methods and Findings in Experimental and Clinical Pharmacology, 23(2), 89-92. Doi:10.1358/mf.2001.23.2.627935
