Effects of Bupivacaine and Ropivacaine on Hemodynamic Parameters in Rabbits

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dc.contributor.authorBarışkaner, H.
dc.contributor.authorTuncer, S.
dc.contributor.authorUlusoy, H.
dc.contributor.authorDoğan, N.
dc.date.accessioned2020-03-26T16:37:05Z
dc.date.available2020-03-26T16:37:05Z
dc.date.issued2001
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn the present study the toxic effects of ropivacaine and bupiavacaine on the cardiovascular and respiratory systems of rabbits were studied. Both drugs were administered intravenously at doses of 0.5, 1, 2.5, 5 and 10 mu mol/kg. The effects of the two drugs on blood pressure, ECG and respiration rate were evaluated by considering the changes occurring 30 sec after intravenous bolus injection. High doses (5 and 10 mu mol/kg) of bupivacaine and ropivacaine significantly reduced the heart rate and systolic pressure (p < 0.05). Five and 10 mu mol/kg of bupivacaine significantly reduced diastolic pressure (p < 0.05), but only the 10 mu mol/kg dose of ropivacaine had the same effect. Low doses of bupivacaine and high doses of ropivacaine significantly increased the PR interval, QRS duration and QT interval (p < 0.05). The 5 mu mol/kg dose of bupivacaine caused ventricular tachycardia in 3 of 6 rabbits, whereas ropivacaine caused tachycardia in 1 of 5 rabbits. Neither drug had a significant effect on respiration rate or blood gas values (p > 0.05). The results indicate that ropivacaine is less cardiodepressive and arrhythmogenic than bupivacaine.en_US
dc.identifier.citationBarışkaner, H., Tuncer, S., Ulusoy, H., Doğan, N., (2001). Effects of Bupivacaine and Ropivacaine on Hemodynamic Parameters in Rabbits. Methods and Findings in Experimental and Clinical Pharmacology, 23(2), 89-92. Doi:10.1358/mf.2001.23.2.627935
dc.identifier.doi10.1358/mf.2001.23.2.627935en_US
dc.identifier.endpage92en_US
dc.identifier.issn0379-0355en_US
dc.identifier.issue2en_US
dc.identifier.pmid11484416en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage89en_US
dc.identifier.urihttps://dx.doi.org/10.1358/mf.2001.23.2.627935
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17533
dc.identifier.volume23en_US
dc.identifier.wosWOS:000169747100007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBarışkaner, H.
dc.institutionauthorTuncer, S.
dc.institutionauthorUlusoy, H.
dc.institutionauthorDoğan, N.
dc.language.isoenen_US
dc.publisherPROUS SCIENCE, SAen_US
dc.relation.ispartofMethods and Findings in Experimental and Clinical Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectBupivacaineen_US
dc.subjectRabbiten_US
dc.subjectRopivacaineen_US
dc.subjectToxic Effecten_US
dc.titleEffects of Bupivacaine and Ropivacaine on Hemodynamic Parameters in Rabbitsen_US
dc.typeArticleen_US

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