Impaired Antioxidant Defense System in the Kidney Tissues from Rabbits Treated with Cyclosporine - Protective Effects of Vitamins E and C
Yükleniyor...
Dosyalar
Tarih
1998
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
KARGER
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Enzymatic antioxidant defense system and antioxidant defense potential (AOP) were studied in kidney tissue from rabbits treated with cyclosporine (CsA, 25 mg/kg/day), antioxidant vitamins (E, 100 mg/kg/day plus C, 200 mg/kg/day), and CsA plus antioxidant vitamins, and in kidney tissue from control animals. Although no change was observed in superoxide dismutase (SOD) activity, glutathione peroxidase (GSH-Px) and catalase (CAT) activities were found decreased in kidney tissue exposed to CsA for 10 days compared with control tissue. The level of thiobarbituric acid-reagent substances (TBARS) was higher and antioxidant defense potential (AOP) lower in the CsA-treated group compared with the other groups. Histopathological examination reveals important subcellular damage in the renal tissue from the animals treated with CsA. Antioxidant vitamin therapy caused full improvement in the enzyme activities, TBARS levels and AOP, but the subcellular damage was partly ameliorated in the CsA plus vitamin group. Results suggest that CsA impairs the antioxidant defense system and reduces the antioxidant defense potential in the renal tissue. Antioxidant vitamin treatment protects the tissue in part against toxic effects of the drug.
Açıklama
Anahtar Kelimeler
cyclosporine, nephrotoxicity, free radicals, antioxidants, antioxidant potential
Kaynak
Nephron
WoS Q Değeri
Q2
Scopus Q Değeri
N/A
Cilt
78
Sayı
2
Künye
Durak, İ, Karabacak, H. İ., Büyükkoçak, S., Çimen, M. Y. B., Kaçmaz, M., Ömeroğlu, E., Öztürk, H. S., (1998). Impaired Antioxidant Defense System in the Kidney Tissues from Rabbits Treated with Cyclosporine - Protective Effects of Vitamins E and C. Nephron, 78(2), 207-211. doi: 10.1159/000044912
