Impaired Antioxidant Defense System in the Kidney Tissues from Rabbits Treated with Cyclosporine - Protective Effects of Vitamins E and C

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dc.contributor.authorDurak, İlker
dc.contributor.authorKarabacak, H. İbrahim
dc.contributor.authorBüyükkoçak, Serap
dc.contributor.authorÇimen, M. Y. Burak
dc.contributor.authorKaçmaz, Murat
dc.contributor.authorÖmeroğlu, Ethem
dc.contributor.authorÖztürk, H. Serdar
dc.date.accessioned2020-03-26T16:26:11Z
dc.date.available2020-03-26T16:26:11Z
dc.date.issued1998
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractEnzymatic antioxidant defense system and antioxidant defense potential (AOP) were studied in kidney tissue from rabbits treated with cyclosporine (CsA, 25 mg/kg/day), antioxidant vitamins (E, 100 mg/kg/day plus C, 200 mg/kg/day), and CsA plus antioxidant vitamins, and in kidney tissue from control animals. Although no change was observed in superoxide dismutase (SOD) activity, glutathione peroxidase (GSH-Px) and catalase (CAT) activities were found decreased in kidney tissue exposed to CsA for 10 days compared with control tissue. The level of thiobarbituric acid-reagent substances (TBARS) was higher and antioxidant defense potential (AOP) lower in the CsA-treated group compared with the other groups. Histopathological examination reveals important subcellular damage in the renal tissue from the animals treated with CsA. Antioxidant vitamin therapy caused full improvement in the enzyme activities, TBARS levels and AOP, but the subcellular damage was partly ameliorated in the CsA plus vitamin group. Results suggest that CsA impairs the antioxidant defense system and reduces the antioxidant defense potential in the renal tissue. Antioxidant vitamin treatment protects the tissue in part against toxic effects of the drug.en_US
dc.identifier.citationDurak, İ, Karabacak, H. İ., Büyükkoçak, S., Çimen, M. Y. B., Kaçmaz, M., Ömeroğlu, E., Öztürk, H. S., (1998). Impaired Antioxidant Defense System in the Kidney Tissues from Rabbits Treated with Cyclosporine - Protective Effects of Vitamins E and C. Nephron, 78(2), 207-211. doi: 10.1159/000044912
dc.identifier.doi10.1159/000044912en_US
dc.identifier.endpage211en_US
dc.identifier.issn0028-2766en_US
dc.identifier.issue2en_US
dc.identifier.pmid9496739en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage207en_US
dc.identifier.urihttps://dx.doi.org/10.1159/000044912
dc.identifier.urihttps://hdl.handle.net/20.500.12395/16768
dc.identifier.volume78en_US
dc.identifier.wosWOS:000071958100014en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKarabacak, H. İbrahim
dc.institutionauthorÖmeroğlu, Ethem
dc.language.isoenen_US
dc.publisherKARGERen_US
dc.relation.ispartofNephronen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcyclosporineen_US
dc.subjectnephrotoxicityen_US
dc.subjectfree radicalsen_US
dc.subjectantioxidantsen_US
dc.subjectantioxidant potentialen_US
dc.titleImpaired Antioxidant Defense System in the Kidney Tissues from Rabbits Treated with Cyclosporine - Protective Effects of Vitamins E and Cen_US
dc.typeArticleen_US

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