SYNTHESIS OF NOVEL DOPAMINE DERIVED MULTIDIRECTIONAL LIGANDS FROM CYANURIC CHLORIDE: STRUCTURAL AND ANTIMICROBIAL STUDIES
Küçük Resim Yok
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
EXCLI JOURNAL MANAGING OFFICE
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Two monopodal (2,4-dichloro-6-(3-hydroxytyramine)-1,3,5-triazine) and tripodal (2,4,6-(3-hydroxytyramine)-1,3,5-triazine) s-triazine derivatives were prepared through the reaction of cyanuric chloride (2,4,6-trichloro-1,3,5-triazine) and 3-hydroxytyramine hydrochloride (dopamine hydrochloride). The structures of the compounds were identified by FT-IR, 1H NMR, 13C NMR, thermal analysis and elemental analysis. Their antimicrobial activities were carried out using the broth microdilution method in dimethyl sulfoxide (DMSO): Phosphate Buffered Saline (PBS) against eight bacteria and one yeast. The results of the test were compared with ampicillin. It was determined that CCDOP1, CCDOP3 and DOP have significant antibacterial and antifungal activity. These three chemicals revealed strong antibacterial activity against the E. coli and S. aureus strains used in the study. S. aureus was the most sensitive strain against dopamine hydrochloride and E. coli was the most sensitive bacteria against CCDOP1.
Açıklama
Anahtar Kelimeler
Cyanuric chloride, dopamine, antimicrobial activity, broth microdilution
Kaynak
EXCLI JOURNAL
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
12
