Evaluation of Chromosome 8 and 11 Aneuploidies in Washings and Biopsy Materials of Bladder Transitional Cell Carcinoma

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dc.contributor.authorAcar, Hasan
dc.contributor.authorKılınç, Mehmet
dc.contributor.authorYıldırım, M. Selman
dc.contributor.authorKaynak, Murat
dc.contributor.authorCenker, Ali
dc.date.accessioned2020-03-26T16:45:45Z
dc.date.available2020-03-26T16:45:45Z
dc.date.issued2003
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractWe compared chromosome 8 and 11 aneuploidies on bladder biopsy tumor tissues and bladder washing samples of transitional cell carcinoma (TCC) and their relationship to tumor malignancy. Interphase fluorescence in situ hybridization (FISH) was applied to nuclei of washing material and biopsy samples of 17 patients with TCC. Incidence of cells having aneuploidy was clearly nonrandom from patient to patient. There was no significant difference in the incidence of aneuploid frequency for chromosomes 8 and I I between biopsies of bladder tumors and bladder washing samples (P > 0.05). For chromosome 8, incidence of disomic cells (having two signals) in grade III tumors was significantly lower than in grade 11 tumors of both washing samples (P = 0.004) and biopsy materials (P = 0.005), indicating a high frequency of aneuploidy. The incidence of nuclei with four or more than four signals of chromosome 8 was significantly higher in grade III tumors than in grade 11 tumors in washing samples (P = 0.031 and 0.003, respectively). Similarly, in biopsy material, the incidence of nuclei with more than four signals of chromosome 8 was significantly higher in grade III tumors than in grade 11 tumors (P = 0.004). For chromosome 11, in both washing samples and biopsy materials, the incidence of disomic cells (having two signals) in grade III tumors was significantly lower than that detected in grade 11 tumors (P = 0.031 and 0.014, respectively), indicating a high frequency of aneuploidy. In biopsy materials, the incidence of nuclei with three or four signals was significantly higher than that in grade 11 tumors (P = 0.014 and 0.012, respectively). These findings suggest that FISH analysis of bladder washing samples can be efffectively detected as genetic changes of bladder tumors. It might predict genetic progression of these tumors, which might be related to tumor stage, because higher stages of tumors showed a higher incidence of aneuploidies of chromosomes 8 and 11. (C) 2003 Elsevier Science Inc. All rights reserved.en_US
dc.identifier.citationAcar, H., Kılınç, M., Yıldırım, M. S., Kaynak, M., Cenker, A., (2003). Evaluation of Chromosome 8 and 11 Aneuploidies in Washings and Biopsy Materials of Bladder Transitional Cell Carcinoma. Cancer Genetics and Cytogenetics, 142(1), 25-29. Doi: 10.1016/S0165-4608(02)00803-8
dc.identifier.doi10.1016/S0165-4608(02)00803-8en_US
dc.identifier.endpage29en_US
dc.identifier.issn0165-4608en_US
dc.identifier.issue1en_US
dc.identifier.pmid12660029en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage25en_US
dc.identifier.urihttps://dx.doi.org/10.1016/S0165-4608(02)00803-8
dc.identifier.urihttps://hdl.handle.net/20.500.12395/18472
dc.identifier.volume142en_US
dc.identifier.wosWOS:000181790300005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAcar, Hasan
dc.institutionauthorKılınç, Mehmet
dc.institutionauthorYıldırım, M. Selman
dc.institutionauthorKaynak, Murat
dc.institutionauthorCenker, Ali
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofCancer Genetics and Cytogeneticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleEvaluation of Chromosome 8 and 11 Aneuploidies in Washings and Biopsy Materials of Bladder Transitional Cell Carcinomaen_US
dc.typeArticleen_US

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