Effects of cooling on histamine-induced contractions of human umbilical artery: The role of ion channels

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dc.contributor.authorAtalik, K. E.
dc.contributor.authorKilic, M.
dc.contributor.authorNurullahqlu, Z. U.
dc.contributor.authorDogan, N.
dc.date.accessioned2020-03-26T17:17:21Z
dc.date.available2020-03-26T17:17:21Z
dc.date.issued2007
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe effects of cooling (to 28 degrees C) on histamine (10(-9) - 3 x 10(-4) M)-induced contractions and the role of calcium (Ca2+), potassium (K-Ca(2+)) and sodium (Na+) channel blockers in the cooling-induced responses were investigated in the endothelium-denuded human umbilical artery. Concentration-response curves to histamine were isometrically recorded at 37 and 28 degrees C (control). The same procedure was repeated at 28 degrees C in the presence of tetraethylammonium (TEA, 10(-3) M), pilsicainide (10(-6) M), ouabain (10-6 M), caffeine (3 X 10-4 M), verapamil (10(-6) M) and also in Ca2+-free medium with ethylene glycol bis-(beta-aminoethyl ether) N,N,N-1,N-1-tetraacetic acid (EGTA). During cooling, the sensitivity, but not the maximal response, was significantly higher than 37 degrees C. Cooling to 28 degrees C after treatment with verapamil or pilsicainide decreased the sensitivity, whereas treatment with TEA and ouabain significantly increased sensitivity. Treatment with caffeine did not modify the effect of cooling. Furthermore, cooling to 28 degrees C after incubation in Ca(2+)free solution with EGTA decreased the sensitivity to histamine. The results of this study suggest the role of Ca2+, K-Ca(2+) and Na+-ion channels in the cooling-induced changes of human umbilical arteries treated with histamine. (C) 2007 Prous Science. All rights reserved.en_US
dc.identifier.doi10.1358/mf.2007.29.9.1116315en_US
dc.identifier.endpage623en_US
dc.identifier.issn0379-0355en_US
dc.identifier.issue9en_US
dc.identifier.pmid18193113en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage619en_US
dc.identifier.urihttps://dx.doi.org/10.1358/mf.2007.29.9.1116315
dc.identifier.urihttps://hdl.handle.net/20.500.12395/21363
dc.identifier.volume29en_US
dc.identifier.wosWOS:000252502600005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPROUS SCIENCE, SAen_US
dc.relation.ispartofMETHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcoolingen_US
dc.subjecthistamineen_US
dc.subjecthuman umbilical arteryen_US
dc.subjectCa2+en_US
dc.subjectK-Ca(2+) and Na+-ion channel blockersen_US
dc.titleEffects of cooling on histamine-induced contractions of human umbilical artery: The role of ion channelsen_US
dc.typeArticleen_US

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