Beneficial Effects of Levosimendan on Cerebral Vasospasm Induced by Subarachnoid Haemorrhage: An Experimental Study

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dc.contributor.authorCengiz, Şahika Liva
dc.contributor.authorErdi, Mehmet Fatih
dc.contributor.authorTosun, Murat
dc.contributor.authorAtalık, Esra
dc.contributor.authorAvunduk, Mustafa Cihat
dc.contributor.authorSönmez, Fatma Cavide
dc.contributor.authorMehmetoğlu, İdris
dc.contributor.authorBaysefer, Alper
dc.date.accessioned2020-03-26T17:47:15Z
dc.date.available2020-03-26T17:47:15Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: The aim of this study was to investigate the ability of levosimendan to prevent cerebral vasospasm in a rabbit model of subarachnoid haemorrhage (SAH). Animals and methods: Eighteen New Zealand white rabbits were allocated into three groups randomly. SAH was induced by injecting autologous blood into the cisterna magna. (Group 1 = control: sham surgery group, Group 2 = SAH alone group, Group 3 = SAH plus levosimendan group). Histopathological examination was performed on day 3 as described. Intravenous levosimendan dose (initially 12 mu g kg(-1) infusion, continuously for at least 10 minutes and then continued with a dose of 0.2 mu g kg(-1) min(-1)) treatment was started after the induction of SAH. Three days later, the animals were sacrificed. Results: In pathological investigation; there was statistically significant difference in luminal area and muscular wall thickness of the basilar artery between all groups (p < 0.005). Malondialdehyde level was also found significantly low in the levosimendan group compared with the SAH group. Conclusion: Intravenous levosimendan treatment was found effective by increasing the pathological luminal area and reducing muscular wall thickness measurements. This is the first study to show that intravenous administration of levosimendan is effective in preventing cerebral vasospasm induced by SAH in rabbits.en_US
dc.identifier.citationCengiz, Ş. L., Erdi, M. F., Tosun, M., Atalık, E., Avunduk, M. C., Sönmez, F. C., Mehmetoğlu, İ., Baysefer, A., (2010). Beneficial Effects of Levosimendan on Cerebral Vasospasm Induced by Subarachnoid Haemorrhage: An Experimental Study. Brain Injury, 24(6), 877-885. Doi: 10.3109/02699051003789260
dc.identifier.doi10.3109/02699051003789260en_US
dc.identifier.endpage885en_US
dc.identifier.issn0269-9052en_US
dc.identifier.issn1362-301Xen_US
dc.identifier.issue6en_US
dc.identifier.pmid20433288en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage877en_US
dc.identifier.urihttps://dx.doi.org/10.3109/02699051003789260
dc.identifier.urihttps://hdl.handle.net/20.500.12395/24656
dc.identifier.volume24en_US
dc.identifier.wosWOS:000279504700010en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorCengiz, Şahika Liva
dc.institutionauthorErdi, Mehmet Fatih
dc.institutionauthorAtalık, Esra
dc.institutionauthorAvunduk, Mustafa Cihat
dc.institutionauthorSönmez, Fatma Cavide
dc.institutionauthorMehmetoğlu, İdris
dc.institutionauthorBaysefer, Alper
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBrain Injuryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAnti-apoptoticen_US
dc.subjectAtp-dependent potassium channels openeren_US
dc.subjectCalcium sensitizeren_US
dc.subjectCerebral vasospasmen_US
dc.subjectPhosphodiesterase inhibitoren_US
dc.subjectLevosimendanen_US
dc.subjectSubarachnoid haemorrhageen_US
dc.subjectVasodilatoren_US
dc.titleBeneficial Effects of Levosimendan on Cerebral Vasospasm Induced by Subarachnoid Haemorrhage: An Experimental Studyen_US
dc.typeArticleen_US

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