Insulin Resistance and Coronary Flow Velocity Reserve in Patients With Autosomal Dominant Polycystic Kidney Disease

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dc.contributor.authorTürkmen, Kültigin
dc.contributor.authorTufan, F.
dc.contributor.authorAlpay, Nilüfer
dc.contributor.authorKaşıkcıoğlu, E.
dc.contributor.authorOflaz, H.
dc.contributor.authorEcder, S. A.
dc.contributor.authorEcder, T.
dc.date.accessioned2020-03-26T18:30:44Z
dc.date.available2020-03-26T18:30:44Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: Cardiovascular problems are a major cause of morbidity and mortality in patients with autosomal dominant polycystic kidney disease (ADPKD). Aim: The aim of this study was to investigate coronary flow velocity reserve (CFVR) as a marker of endothelial dysfunction, carotid intima media thickness (CIMT) as a marker of subclinical organ damage and insulin resistance (IR) as a cardiovascular risk factor in patients with ADPKD. Methods: Twenty-two normotensive ADPKD patients with well-preserved renal function and 19 healthy subjects were included in the study. Creatinine clearances were calculated by the Cockcroft-Gault formula. The homeostasis model of IR (HOMA-IR) was used to measure IR. CIMT was measured by high-resolution vascular ultrasound. CFVR was calculated as the ratio of hyperaemic to baseline diastolic peak velocities by echocardiography. Results: There was no significant difference between the two groups regarding age, gender, body mass index, systolic and diastolic blood pressures, cholesterol and triglyceride levels. However, CIMT and HOMA-IR were significantly increased and CFVR was significantly decreased in patients with ADPKD compared with healthy subjects. Conclusions: The findings of decreased CFVR, increased CIMT and increased IR suggest that cardiovascular risk is elevated even in the early stages of ADPKD.en_US
dc.identifier.citationTurkmen, K., Tufan, F., Alpay, N., Kasikcioglu, E., Oflaz, H., Ecder, S. A., (2012). Insulin Resistance and Coronary Flow Velocity Reserve in Patients With Autosomal Dominant Polycystic Kidney Disease. Internal Medicine Journal, 42(2), 146-153. DOI:10.1111/j.1445-5994.2010.02404.x
dc.identifier.doi10.1111/j.1445-5994.2010.02404.xen_US
dc.identifier.endpage153en_US
dc.identifier.issn1444-0903en_US
dc.identifier.issn1445-5994en_US
dc.identifier.issue2en_US
dc.identifier.pmid21118411en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage146en_US
dc.identifier.urihttps://dx.doi.org/10.1111/j.1445-5994.2010.02404.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/28148
dc.identifier.volume42en_US
dc.identifier.wosWOS:000300694700006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofInternal Medicine Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectautosomal domimant polycystic diseaseen_US
dc.subjectinsulin resistanceen_US
dc.subjectcoronary flow velocity reserveen_US
dc.titleInsulin Resistance and Coronary Flow Velocity Reserve in Patients With Autosomal Dominant Polycystic Kidney Diseaseen_US
dc.typeArticleen_US

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